Raghavan Varadarajan
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Explore the profile of Raghavan Varadarajan including associated specialties, affiliations and a list of published articles.
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Articles
130
Citations
1947
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Recent Articles
1.
Singh N, Chattopadhyay G, Sundaramoorthy N, Varadarajan R, Singh R
Commun Biol
. 2025 Feb;
8(1):327.
PMID: 40016306
The VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex. Here, we have...
2.
Ghoshal B, Chakraborty D, Nag M, Varadarajan R, Jhunjhunwala S
ACS Bio Med Chem Au
. 2024 Dec;
4(6):291-299.
PMID: 39712209
Base modification and the use of lipid nanoparticles are thought to be essential for efficient in vivo delivery and expression of mRNA. However, for ex vivo immune cell engineering, the...
3.
Sharma A, Singh N, Bhasin M, Tiwari P, Chopra P, Varadarajan R, et al.
Commun Biol
. 2024 Oct;
7(1):1417.
PMID: 39478197
The expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26...
4.
Jia J, Cohen C, Gu H, McLean M, Varadarajan R, Bhandari N, et al.
Nat Commun
. 2024 Sep;
15(1):8227.
PMID: 39300094
No abstract available.
5.
Nanda B, Bhowmick J, Varadarajan R, Sarma S
Biomol NMR Assign
. 2024 Sep;
18(2):285-292.
PMID: 39276296
The CcdAB system expressed in the E.coli cells is a prototypical example of the bacterial toxin-antitoxin (TA) systems that ensure the survival of the bacterial population under adverse environmental conditions....
6.
Ganesan S, Mittal N, Bhat A, Adiga R, Ganesan A, Nagarajan D, et al.
Proteins
. 2024 Aug;
93(1):384-395.
PMID: 39166462
While many computational methods accurately predict destabilizing mutations, identifying stabilizing mutations has remained a challenge, because of their relative rarity. We tested ΔΔG predictions from computational predictors such as Rosetta,...
7.
Liang Z, Lin X, Sun L, Edwards K, Song W, Sun H, et al.
Nat Commun
. 2024 Jul;
15(1):5593.
PMID: 38961067
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the...
8.
Jia J, Cohen C, Gu H, McLean M, Varadarajan R, Bhandari N, et al.
Nat Commun
. 2024 Apr;
15(1):3210.
PMID: 38615070
Cross-reactive antibodies with Fc receptor (FcR) effector functions may mitigate pandemic virus impact in the absence of neutralizing antibodies. In this exploratory study, we use serum from a randomized placebo-controlled...
9.
Khan M, Jakob V, Singh R, Rajmani R, Kumar S, Lemoine C, et al.
Pharmaceutics
. 2023 Dec;
15(12).
PMID: 38140101
Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized...
10.
Bajaj P, Bhasin M, Varadarajan R
BMC Genomics
. 2023 Dec;
24(1):732.
PMID: 38049728
Background: Single synonymous codon mutations typically have only minor or no effects on gene function. Here, we estimate the effects on cell growth of ~ 200 single synonymous codon mutations...