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» Authors » Kausik Chattopadhyay

Kausik Chattopadhyay

Explore the profile of Kausik Chattopadhyay including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 57
Citations 588
Followers 0
Related Specialties
Biochemistry
Biology
Chemistry
Top 10 Co-Authors
Kusum Lata
Anish Kumar Mondal
Pratima Verma
Anand Kumar Rai
Bimalendu Ray
Mahendra Singh
Karan Paul
Somnath Dutta
Stanley G Nathenson
Arunika Mukhopadhaya
Published In
Biochemistry
Biochem J
J Biol Chem
Mol Microbiol
Phytochemistry
Affiliations
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Recent Articles
1.
Mechanistic Cooperation of the Two Pore-Forming Transmembrane Motifs Regulates the β-Barrel Pore Formation by Listeriolysin O
Lata K, Nandy K, Geetika , Chattopadhyay K
Biochemistry . 2025 Jan; 64(4):917-927. PMID: 39869763
Listeriolysin O (LLO) is a potent membrane-damaging pore-forming toxin (PFT) secreted by the bacterial pathogen . LLO belongs to the family of cholesterol-dependent cytolysins (CDCs), which specifically target cholesterol-containing cell...
2.
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function
Chatterjee S, Gupta T, Kaur G, Chattopadhyay K
Biochem J . 2024 Nov; 481(22):1679-1705. PMID: 39503596
Gasdermin D (GSDMD) is the chief executioner of inflammatory cell death or pyroptosis. During pyroptosis, proteolytic processing of GSDMD releases its N-terminal domain (NTD), which then forms large oligomeric pores...
3.
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation
Lata K, Anderluh G, Chattopadhyay K
Biochem J . 2024 Sep; 481(19):1349-1377. PMID: 39268843
Cholesterol-dependent cytolysins (CDCs) are the distinct class of β-barrel pore-forming toxins (β-PFTs) that attack eukaryotic cell membranes, and form large, oligomeric, transmembrane β-barrel pores. Listeriolysin O (LLO) is a prominent...
4.
Elucidating photocycle in large Stokes shift red fluorescent proteins: Focus on mKeima
Bhutani G, Verma P, Paul S, Dhamija S, Chattopadhyay K, De A
Photochem Photobiol . 2024 May; 100(4):897-909. PMID: 38752609
Large Stokes shift red fluorescent proteins (LSS-RFPs) are genetically encoded and exhibit a significant difference of a few hundreds of nanometers between their excitation and emission peak maxima (i.e., the...
5.
Vibrio parahaemolyticus thermostable direct haemolysin induces non-classical programmed cell death despite caspase activation
Verma P, Chauhan A, Thakur R, Lata K, Sharma A, Chattopadhyay K, et al.
Mol Microbiol . 2023 Oct; 120(6):845-873. PMID: 37818865
Thermostable direct haemolysin (TDH) is the key virulence factor secreted by the human gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a membrane-damaging pore-forming toxin. It evokes potent cytotoxicity, the mechanism...
6.
Unveiling the Role of Hidden Isomers in Large Stokes Shift in mKeima: Harnessing pH-Sensitive Dual-Emission in Bioimaging
Bhutani G, Verma P, Jayachandran A, Paul S, Chattopadhyay K, De A
J Phys Chem B . 2023 Apr; 127(14):3197-3207. PMID: 37014205
Elucidating the origin of large Stokes shift (LSS) in certain fluorescent proteins absorbing in blue/blue-green and emitting in red/far-red has been quite illusive. Using a combination of spectroscopic measurements, corroborated...
7.
Pore formation-independent cell death induced by a β-barrel pore-forming toxin
Kaur D, Verma P, Singh M, Sharma A, Lata K, Mukhopadhaya A, et al.
FASEB J . 2022 Sep; 36(10):e22557. PMID: 36125006
Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). It exhibits potent hemolytic activity against erythrocytes that appears to be a direct outcome of its pore-forming functionality. However, VCC-mediated...
8.
Glu289 residue in the pore-forming motif of Vibrio cholerae cytolysin is important for efficient β-barrel pore formation
Mondal A, Sengupta N, Singh M, Biswas R, Lata K, Lahiri I, et al.
J Biol Chem . 2022 Sep; 298(10):102441. PMID: 36055404
Vibrio cholerae cytolysin (VCC) is a potent membrane-damaging β-barrel pore-forming toxin. Upon binding to the target membranes, VCC monomers first assemble into oligomeric prepore intermediates and subsequently transform into transmembrane...
9.
Structural insights into thermostable direct hemolysin of Vibrio parahaemolyticus using single-particle cryo-EM
Mishra S, Kundu N, Pramanick I, Kumar A, Chattopadhyay K, Dutta S
Proteins . 2022 Aug; 91(2):137-146. PMID: 36000388
Thermostable direct hemolysin (TDH) is a ~19 kDa, hemolytic pore-forming toxin from the gram-negative marine bacterium Vibrio parahaemolyticus, one of the causative agents of seafood-borne acute gastroenteritis and septicemia. Previous...
10.
Cryo-EM elucidates mechanism of action of bacterial pore-forming toxins
Mondal A, Lata K, Singh M, Chatterjee S, Chauhan A, Puravankara S, et al.
Biochim Biophys Acta Biomembr . 2022 Jul; 1864(11):184013. PMID: 35908609
Pore-forming toxins (PFTs) rupture plasma membranes and kill target cells. PFTs are secreted as soluble monomers that undergo drastic structural rearrangements upon interacting with the target membrane and generate transmembrane...