Somnath Dutta
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Explore the profile of Somnath Dutta including associated specialties, affiliations and a list of published articles.
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51
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1222
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Recent Articles
11.
Mondal A, Sengupta N, Singh M, Biswas R, Lata K, Lahiri I, et al.
J Biol Chem
. 2022 Sep;
298(10):102441.
PMID: 36055404
Vibrio cholerae cytolysin (VCC) is a potent membrane-damaging β-barrel pore-forming toxin. Upon binding to the target membranes, VCC monomers first assemble into oligomeric prepore intermediates and subsequently transform into transmembrane...
12.
Mishra S, Kundu N, Pramanick I, Kumar A, Chattopadhyay K, Dutta S
Proteins
. 2022 Aug;
91(2):137-146.
PMID: 36000388
Thermostable direct hemolysin (TDH) is a ~19 kDa, hemolytic pore-forming toxin from the gram-negative marine bacterium Vibrio parahaemolyticus, one of the causative agents of seafood-borne acute gastroenteritis and septicemia. Previous...
13.
Dutta S, Liu N, Gao Y, Beck L, Wang X
Bioorg Med Chem Lett
. 2022 Jul;
72:128878.
PMID: 35788034
Multidrug-resistant (MDR) Gram-negative bacteria are an urgent and rapidly spreading threat to human health with limited treatment options. Previously, we discovered a novel [1,2,5]oxadiazolo[3,4-b]pyrazine-containing compound (1) that selectively re-sensitized a...
14.
Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, et al.
Sci Adv
. 2022 Jun;
8(25):eabo0097.
PMID: 35749503
Methionine and cysteine metabolisms are important for the survival and pathogenesis of (). The transsulfuration pathway converts methionine to cysteine and represents an important link between antioxidant and methylation metabolism...
15.
Kar U, Khaleeq S, Garg P, Bhat M, Reddy P, Vignesh V, et al.
Front Immunol
. 2022 Jun;
13:890622.
PMID: 35720346
Current influenza vaccines need to be updated annually due to mutations in the globular head of the viral surface protein, hemagglutinin (HA). To address this, vaccine candidates have been designed...
16.
Khatri B, Pramanick I, Malladi S, Rajmani R, Kumar S, Ghosh P, et al.
Nat Chem Biol
. 2022 Jun;
18(10):1046-1055.
PMID: 35654847
Protein tertiary structure mimetics are valuable tools to target large protein-protein interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin motifs from a previously reported three-helix-bundle miniprotein that...
17.
Gao Y, Dutta S, Wang X
ACS Omega
. 2022 Apr;
7(14):12442-12446.
PMID: 35449921
Antibiotic resistance is a growing global health concern. Colistin is one of the last-resort antibiotics that treats multidrug-resistant (MDR) Gram-negative bacterial infection. However, bacteria resistant to colistin have become increasingly...
18.
Biswas S, Garg P, Dutta S, Suguna K
Sci Rep
. 2021 Oct;
11(1):21023.
PMID: 34697325
The structures of a cyanophage small heat shock protein (sHSP) were determined as octahedrons of 24-mers and 48-mers and as icosahedrons of 60-mers. An N-terminal deletion construct of an 18 ...
19.
Sengupta N, Mondal A, Mishra S, Chattopadhyay K, Dutta S
J Cell Biol
. 2021 Oct;
220(12).
PMID: 34617964
Vibrio cholerae cytolysin (VCC) is a water-soluble, membrane-damaging, pore-forming toxin (PFT) secreted by pathogenic V. cholerae, which causes eukaryotic cell death by altering the plasma membrane permeability. VCC self-assembles on...
20.
Mittal N, Sengupta N, Malladi S, Reddy P, Bhat M, Rajmani R, et al.
Viruses
. 2021 Sep;
13(9).
PMID: 34578291
In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin...