Sheldon Milstien
Overview
Explore the profile of Sheldon Milstien including associated specialties, affiliations and a list of published articles.
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120
Citations
10726
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Recent Articles
1.
James B, Weigel C, Green C, Brown R, Palladino E, Tharakan A, et al.
FASEB J
. 2023 Feb;
37(3):e22799.
PMID: 36753412
Genome-wide association studies have linked the ORM (yeast)-like protein isoform 3 (ORMDL3) to asthma severity. Although ORMDL3 is a member of a family that negatively regulates serine palmitoyltransferase (SPT) and...
2.
Weigel C, Maczis M, Palladino E, Green C, Maceyka M, Guo C, et al.
Cancer Res
. 2022 Dec;
83(4):553-567.
PMID: 36541910
Significance: Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.
3.
Palladino E, Bernas T, Green C, Weigel C, Singh S, Senkal C, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(39):e2204396119.
PMID: 36122218
Membrane contact sites (MCS), close membrane apposition between organelles, are platforms for interorganellar transfer of lipids including cholesterol, regulation of lipid homeostasis, and co-ordination of endocytic trafficking. Sphingosine kinases (SphKs),...
4.
James B, Oyeniran C, Sturgill J, Newton J, Martin R, Bieberich E, et al.
J Allergy Clin Immunol
. 2020 Nov;
147(5):1936-1948.e9.
PMID: 33130063
Background: Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity. Objective: We sought to investigate the functional role...
5.
Newton J, Palladino E, Weigel C, Maceyka M, Graler M, Senkal C, et al.
J Biol Chem
. 2020 May;
295(27):9121-9133.
PMID: 32385114
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These mutations result in accumulation of low-density lipoprotein-derived...
6.
James B, Milstien S, Spiegel S
J Allergy Clin Immunol
. 2019 Aug;
144(3):634-640.
PMID: 31376405
There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein 3 (ORMDL3) as a gene associated with asthma susceptibility. However, how ORMDL3...
7.
Maceyka M, Rohrbach T, Milstien S, Spiegel S
Handb Exp Pharmacol
. 2019 Jul;
259:3-17.
PMID: 31321542
Hepatocellular carcinoma (HCC) is primarily diagnosed in the latter stages of disease progression and is the third leading cause of cancer deaths worldwide. Thus, there is a need to find...
8.
Spiegel S, Maczis M, Maceyka M, Milstien S
J Lipid Res
. 2019 Jan;
60(3):484-489.
PMID: 30655317
Sphingosine-1-phosphate (S1P) is a potent bioactive signaling molecule that regulates many physiological processes important for development, epithelial and endothelial barrier integrity, and the immune system, as well as for pathologies,...
9.
Maczis M, Maceyka M, Waters M, Newton J, Singh M, Rigsby M, et al.
J Lipid Res
. 2018 Oct;
59(12):2297-2307.
PMID: 30315000
In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2...
10.
Newton J, Milstien S, Spiegel S
Adv Biol Regul
. 2018 Sep;
70:82-88.
PMID: 30205942
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder resulting from mutations in either the NPC1 (95%) or NPC2 (5%) genes. NPC typically presents in childhood with visceral lipid...