Sarah Spiegel
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Explore the profile of Sarah Spiegel including associated specialties, affiliations and a list of published articles.
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16356
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Recent Articles
1.
Pondelick A, Moncayo L, Donvito G, McLane V, Gillespie J, Hauser K, et al.
Neuropharmacology
. 2024 Sep;
261:110165.
PMID: 39303855
Sphingosine-1-phosphate (S1P) receptor (S1PR) agonists, such as fingolimod (FTY720), alleviate nociception in preclinical pain models by either activation (agonism) or inhibition (functional antagonism) of S1PR type-1 (S1PR1). However, the dose-dependence...
2.
Singh S, Weigel C, Brown R, Green C, Tuck C, Salvemini D, et al.
FASEB J
. 2024 Aug;
38(15):e23872.
PMID: 39126272
Paclitaxel is among the most active chemotherapy drugs for the aggressive triple negative breast cancer (TNBC). Unfortunately, it often induces painful peripheral neuropathy (CIPN), a major debilitating side effect. Here...
3.
Green C, Brown R, Uranbileg B, Weigel C, Saha S, Kurano M, et al.
Mol Metab
. 2024 Jun;
86:101971.
PMID: 38925249
Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality, and its incidence is increasing due to endemic obesity. HCC is sexually dimorphic in both humans and rodents...
4.
Brown R, Mahawar U, Wattenberg B, Spiegel S
J Lipid Res
. 2024 May;
65(6):100556.
PMID: 38719150
Niemann-Pick type C1 (NPC1) disease is a rare neurodegenerative cholesterol and sphingolipid storage disorder primarily due to mutations in the cholesterol-trafficking protein NPC1. In addition to catabolic-derived sphingolipids, NPC1 dysfunction...
5.
Brown R, Green C, Weigel C, Ni B, Celi F, Proia R, et al.
Mol Metab
. 2023 Dec;
79:101851.
PMID: 38081412
Objective: The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) accumulate with overnutrition and have been implicated in non-alcoholic steatohepatitis (NASH) development. ORMDL3, a negative regulator of the rate-limiting step in...
6.
Fohmann I, Weinmann A, Schumacher F, Peters S, Prell A, Weigel C, et al.
PLoS Pathog
. 2023 Nov;
19(11):e1011842.
PMID: 38033162
Invasion of brain endothelial cells (BECs) is central to the pathogenicity of Neisseria meningitidis infection. Here, we established a key role for the bioactive sphingolipid sphingosine-1-phosphate (S1P) and S1P receptor...
7.
Hempelmann P, Lolicato F, Graziadei A, Brown R, Spiegel S, Rappsilber J, et al.
bioRxiv
. 2023 Oct;
PMID: 37790546
Sphingolipids are important structural components of membranes. Additionally, simple sphingolipids such as sphingosine are highly bioactive and participate in complex subcellular signaling. Sphingolipid deregulation is associated with many severe diseases...
8.
Weigel C, Bellaci J, Spiegel S
J Biol Chem
. 2023 May;
299(6):104775.
PMID: 37142226
The vascular and lymphatic systems both comprise a series of structurally distinct vessels lined with an inner layer of endothelial cells that function to provide a semipermeable barrier to blood...
9.
Brown R, Spiegel S
Pharmacol Ther
. 2023 Apr;
245:108401.
PMID: 37003301
Obesity is a key risk factor for the development of metabolic disease. Bioactive sphingolipid metabolites are among the lipids increased in obesity. Obesogenic saturated fatty acids are substrates for serine...
10.
James B, Weigel C, Green C, Brown R, Palladino E, Tharakan A, et al.
FASEB J
. 2023 Feb;
37(3):e22799.
PMID: 36753412
Genome-wide association studies have linked the ORM (yeast)-like protein isoform 3 (ORMDL3) to asthma severity. Although ORMDL3 is a member of a family that negatively regulates serine palmitoyltransferase (SPT) and...