ORMDL3 and Allergic Asthma: From Physiology to Pathology

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2019 Aug 4

PMID 31376405

Citations 35

Authors

Briana James

Sheldon Milstien

Sarah Spiegel

Affiliations

Soon will be listed here.

Abstract

There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein 3 (ORMDL3) as a gene associated with asthma susceptibility. However, how ORMDL3 contributes to asthma pathogenesis and its physiologic functions is not well understood and a matter of great debate. This rostrum describes recent advances and new insights in understanding of the multifaceted functions of ORMDL3 in patients with allergic asthma. We also suggest a potential unifying paradigm and discuss molecular mechanisms for the pathologic functions of ORMDL3 in asthma related to its evolutionarily conserved role in regulation of sphingolipid homeostasis. Finally, we briefly survey the utility of sphingolipid metabolites as potential biomarkers for allergic asthma.

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