Michael Maceyka
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Explore the profile of Michael Maceyka including associated specialties, affiliations and a list of published articles.
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49
Citations
5213
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Recent Articles
1.
Weigel C, Maczis M, Palladino E, Green C, Maceyka M, Guo C, et al.
Cancer Res
. 2022 Dec;
83(4):553-567.
PMID: 36541910
Significance: Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.
2.
Green C, Maceyka M, Cowart L, Spiegel S
Cell Metab
. 2021 Jul;
33(7):1293-1306.
PMID: 34233172
The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a recent addition to the lipids accumulated in obesity and have emerged as important molecular players in metabolic diseases. Here we...
3.
Green C, Weigel C, Oyeniran C, James B, Davis D, Mahawar U, et al.
J Lipid Res
. 2021 May;
62:100082.
PMID: 33939982
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT....
4.
Thompson J, Maceyka M, Chen Q
Mech Ageing Dev
. 2020 Oct;
192:111380.
PMID: 33045249
Severity of cardiovascular disease increases markedly in elderly patients. In addition, many therapeutic strategies that decrease cardiac injury in adult patients are invalid in elderly patients. Thus, it is a...
5.
Newton J, Palladino E, Weigel C, Maceyka M, Graler M, Senkal C, et al.
J Biol Chem
. 2020 May;
295(27):9121-9133.
PMID: 32385114
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These mutations result in accumulation of low-density lipoprotein-derived...
6.
Maceyka M, Rohrbach T, Milstien S, Spiegel S
Handb Exp Pharmacol
. 2019 Jul;
259:3-17.
PMID: 31321542
Hepatocellular carcinoma (HCC) is primarily diagnosed in the latter stages of disease progression and is the third leading cause of cancer deaths worldwide. Thus, there is a need to find...
7.
Rodriguez-Agudo D, Malacrida L, Kakiyama G, Sparrer T, Fortes C, Maceyka M, et al.
J Lipid Res
. 2019 Apr;
60(6):1087-1098.
PMID: 31015253
How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain (StarD)5 leads to a decrease in...
8.
Spiegel S, Maczis M, Maceyka M, Milstien S
J Lipid Res
. 2019 Jan;
60(3):484-489.
PMID: 30655317
Sphingosine-1-phosphate (S1P) is a potent bioactive signaling molecule that regulates many physiological processes important for development, epithelial and endothelial barrier integrity, and the immune system, as well as for pathologies,...
9.
Maczis M, Maceyka M, Waters M, Newton J, Singh M, Rigsby M, et al.
J Lipid Res
. 2018 Oct;
59(12):2297-2307.
PMID: 30315000
In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2...
10.
Rohrbach T, Maceyka M, Spiegel S
Crit Rev Biochem Mol Biol
. 2017 Jun;
52(5):543-553.
PMID: 28618839
Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for...