Shawn C Burgess
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Explore the profile of Shawn C Burgess including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Metabolic and Transcriptomic Insights into Controlled Hypothermic Preservation of Human Donor Hearts
Sharma G, Vela R, Powell L, Deja S, Fu X, Burgess S, et al.
J Heart Lung Transplant
. 2025 Mar;
PMID: 40081628
Background: Heart transplantation (HT) is the gold standard for end-stage heart disease. Donor heart preservation is an important factor that influences post-transplant success. Recently, temperature-controlled storage has demonstrated reduced primary...
2.
Kugler B, Maurer A, Fu X, Franczak E, Ernst N, Schwartze K, et al.
bioRxiv
. 2024 Nov;
PMID: 39484384
High cardiorespiratory fitness and exercise show evidence of altering bile acid (BA) metabolism and are known to protect or treat diet-induced hepatic steatosis, respectively. Here, we tested the hypothesis that...
3.
Rauckhorst A, Sheldon R, Pape D, Ahmed A, Falls-Hubert K, Merrill R, et al.
Cell Metab
. 2024 Oct;
37(1):255-273.e6.
PMID: 39471817
Hepatic de novo lipogenesis (DNL) is a fundamental physiologic process that is often pathogenically elevated in metabolic disease. Treatment is limited by incomplete understanding of the metabolic pathways supplying cytosolic...
4.
Eller M, Zuberi A, Fu X, Burgess S, Lutz C, Bailey R
bioRxiv
. 2024 Jun;
PMID: 38915588
ECHS1 Deficiency (ECHS1D) is a rare and devastating pediatric disease that currently has no defined treatments. This disorder results from missense loss-of-function mutations in the gene that result in severe...
5.
Elnwasany A, Ewida H, Menendez-Montes I, Mizerska M, Fu X, Kim C, et al.
J Biol Chem
. 2024 May;
300(7):107412.
PMID: 38796064
The heart alters the rate and relative oxidation of fatty acids and glucose based on availability and energetic demand. Insulin plays a crucial role in this process diminishing fatty acid...
6.
Deja S, Fletcher J, Kim C, Kucejova B, Fu X, Mizerska M, et al.
Cell Metab
. 2024 Mar;
36(5):1088-1104.e12.
PMID: 38447582
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also...
7.
Yiew N, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, et al.
iScience
. 2023 Nov;
26(11):108196.
PMID: 37942005
The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via lipogenesis (DNL) when carbohydrates are abundant. Mitochondrial pyruvate...
8.
Onodera T, Wang M, Rutkowski J, Deja S, Chen S, Balzer M, et al.
Nat Commun
. 2023 Oct;
14(1):6531.
PMID: 37848446
Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but...
9.
Fu X, Fletcher J, Deja S, Inigo-Vollmer M, Burgess S, Browning J
J Clin Invest
. 2023 Mar;
133(9).
PMID: 36928190
BACKGROUNDHepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated, and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver (NAFL). Fasting normally relaxes DNL-mediated inhibition...
10.
Goncalves R, Wang Z, Inouye K, Lee G, Fu X, Saksi J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865319
Mitochondrial reactive oxygen species (mROS) are central to physiology. While excess mROS production has been associated with several disease states, its precise sources, regulation, and mechanism of generation remain unknown,...