Stanislaw Deja
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Explore the profile of Stanislaw Deja including associated specialties, affiliations and a list of published articles.
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34
Citations
924
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Recent Articles
1.
Metabolic and Transcriptomic Insights into Controlled Hypothermic Preservation of Human Donor Hearts
Sharma G, Vela R, Powell L, Deja S, Fu X, Burgess S, et al.
J Heart Lung Transplant
. 2025 Mar;
PMID: 40081628
Background: Heart transplantation (HT) is the gold standard for end-stage heart disease. Donor heart preservation is an important factor that influences post-transplant success. Recently, temperature-controlled storage has demonstrated reduced primary...
2.
Pudelko-Malik N, Drulis-Fajdasz D, Fydryszewski M, Burgess S, Mlynarz P, Rakus D, et al.
bioRxiv
. 2025 Mar;
PMID: 40060682
Glucose is a predominant fuel for the brain supporting its high energy demand associated with neuronal signaling and synaptic activity. Long-term potentiation (LTP) is required for learning and memory formation...
3.
Rauckhorst A, Sheldon R, Pape D, Ahmed A, Falls-Hubert K, Merrill R, et al.
Cell Metab
. 2024 Oct;
37(1):255-273.e6.
PMID: 39471817
Hepatic de novo lipogenesis (DNL) is a fundamental physiologic process that is often pathogenically elevated in metabolic disease. Treatment is limited by incomplete understanding of the metabolic pathways supplying cytosolic...
4.
Deja S, Fletcher J, Kim C, Kucejova B, Fu X, Mizerska M, et al.
Cell Metab
. 2024 Mar;
36(5):1088-1104.e12.
PMID: 38447582
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also...
5.
Yiew N, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, et al.
iScience
. 2023 Nov;
26(11):108196.
PMID: 37942005
The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via lipogenesis (DNL) when carbohydrates are abundant. Mitochondrial pyruvate...
6.
Onodera T, Wang M, Rutkowski J, Deja S, Chen S, Balzer M, et al.
Nat Commun
. 2023 Oct;
14(1):6531.
PMID: 37848446
Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but...
7.
Fu X, Fletcher J, Deja S, Inigo-Vollmer M, Burgess S, Browning J
J Clin Invest
. 2023 Mar;
133(9).
PMID: 36928190
BACKGROUNDHepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated, and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver (NAFL). Fasting normally relaxes DNL-mediated inhibition...
8.
Yiew N, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, et al.
bioRxiv
. 2023 Feb;
PMID: 36824879
The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via lipogenesis (DNL) when carbohydrates are abundant. Mitochondrial pyruvate...
9.
Deja S, Crawford P, Burgess S
Cell Metab
. 2022 May;
34(5):658-660.
PMID: 35508108
In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle...
10.
Rahim M, Ragavan M, Deja S, Merritt M, Burgess S, Young J
Metab Eng
. 2021 Dec;
69:275-285.
PMID: 34965470
Metabolic flux analysis (MFA) combines experimental measurements and computational modeling to determine biochemical reaction rates in live biological systems. Advancements in analytical instrumentation, such as nuclear magnetic resonance (NMR) spectroscopy...