Matthew E Merritt
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Explore the profile of Matthew E Merritt including associated specialties, affiliations and a list of published articles.
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108
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2602
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Recent Articles
1.
Clarke H, Hawkinson T, Shedlock C, Medina T, Ribas R, Wu L, et al.
Nat Metab
. 2025 Mar;
PMID: 40069440
Lung adenocarcinoma (LUAD) is an aggressive cancer defined by oncogenic drivers and metabolic reprogramming. Here we leverage next-generation spatial screens to identify glycogen as a critical and previously underexplored oncogenic...
2.
McLeod M, Chang M, Rushin A, Ragavan M, Mahar R, Sharma G, et al.
Cell Rep Med
. 2024 Sep;
5(9):101714.
PMID: 39241774
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe hepatocyte...
3.
Cilenti L, Di Gregorio J, Mahar R, Liu F, Ambivero C, Periasamy M, et al.
Front Mol Biosci
. 2024 May;
11:1397565.
PMID: 38725872
Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have...
4.
Febo M, Mahar R, Rodriguez N, Buraima J, Pompilus M, Pinto A, et al.
Front Aging Neurosci
. 2024 Mar;
16:1356086.
PMID: 38524115
Introduction: The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors...
5.
Ma X, Shedlock C, Medina T, Ribas R, Clarke H, Hawkinson T, et al.
bioRxiv
. 2023 Dec;
PMID: 38077043
High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin...
6.
Febo M, Mahar R, Rodriguez N, Buraima J, Pompilus M, Pinto A, et al.
bioRxiv
. 2023 Nov;
PMID: 38014219
The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have...
7.
Chang M, Staklinski S, Merritt M, Kilberg M
Biol Methods Protoc
. 2023 Nov;
8(1):bpad026.
PMID: 37965492
Human asparagine synthetase (ASNS) catalyzes the conversion of aspartate to asparagine in an ATP-dependent reaction that utilizes glutamine as a nitrogen source while generating glutamate, AMP, and pyrophosphate as additional...
8.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang M, et al.
Cell Metab
. 2023 Aug;
35(10):1830-1843.e5.
PMID: 37611583
Stable isotopes are powerful tools to assess metabolism. C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate...
9.
Rushin A, McLeod M, Ragavan M, Merritt M
Magn Reson Chem
. 2023 Jul;
61(12):748-758.
PMID: 37482899
In a clinical setting, ex vivo perfusions are routinely used to maintain and assess organ viability prior to transplants. Organ perfusions are also a model system to examine metabolic flux...
10.
Chang M, Staklinski S, Malut V, Pierre G, Kilberg M, Merritt M
Nutrients
. 2023 Apr;
15(8).
PMID: 37111157
The natural amino acid asparagine (Asn) is required by cells to sustain function and proliferation. Healthy cells can synthesize Asn through asparagine synthetase (ASNS) activity, whereas specific cancer and genetically...