Sebastien A Smallwood
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Explore the profile of Sebastien A Smallwood including associated specialties, affiliations and a list of published articles.
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24
Citations
2166
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Recent Articles
1.
Skribbe M, Soneson C, Stadler M, Schwaiger M, Suma Sreechakram V, Iesmantavicius V, et al.
Mol Cell
. 2025 Feb;
PMID: 40015273
Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyces pombe, one-third of TFs are solely homology predicted,...
2.
Fanourgakis G, Gaspa-Toneu L, Komarov P, Papasaikas P, Ozonov E, Smallwood S, et al.
Nat Commun
. 2025 Jan;
16(1):465.
PMID: 39774947
In the germ line and during early embryogenesis, DNA methylation (DNAme) undergoes global erasure and re-establishment to support germ cell and embryonic development. While DNAme acquisition during male germ cell...
3.
Olivieri D, Paramanathan S, Bardet A, Hess D, Smallwood S, Elling U, et al.
J Biol Chem
. 2021 Jul;
297(2):100947.
PMID: 34270961
Transcription factors (TFs) harboring broad-complex, tramtrack, and bric-a-brac (BTB) domains play important roles in development and disease. These BTB domains are thought to recruit transcriptional modulators to target DNA regions....
4.
Grand R, Burger L, Grawe C, Michael A, Isbel L, Hess D, et al.
Nature
. 2021 Jul;
596(7870):133-137.
PMID: 34234345
The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters, yet our understanding of their regulation remains limited. This is in...
5.
Olivieri D, Castelli E, Kawamura Y, Papasaikas P, Lukonin I, Rittirsch M, et al.
EMBO J
. 2021 Apr;
40(12):e106818.
PMID: 33909924
Mouse embryonic stem cells (mESCs) are biased toward producing embryonic rather than extraembryonic endoderm fates. Here, we identify the mechanism of this barrier and report that the histone deacetylase Hdac3...
6.
Ginno P, Gaidatzis D, Feldmann A, Hoerner L, Imanci D, Burger L, et al.
Nat Commun
. 2020 May;
11(1):2680.
PMID: 32471981
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary during differentiation and in diseases such as cancer. Local levels of DNA methylation result from opposing enzymatic...
7.
Redolfi J, Zhan Y, Valdes-Quezada C, Kryzhanovska M, Guerreiro I, Iesmantavicius V, et al.
Nat Struct Mol Biol
. 2019 May;
26(6):471-480.
PMID: 31133702
Current understanding of chromosome folding is largely reliant on chromosome conformation capture (3C)-based experiments, where chromosomal interactions are detected as ligation products after chromatin crosslinking. To measure chromosome structure in...
8.
Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler M, Zinner M, et al.
Cell Stem Cell
. 2019 Jan;
24(2):257-270.e8.
PMID: 30595499
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression. In an unbiased genome-wide...
9.
Rulands S, Lee H, Clark S, Angermueller C, Smallwood S, Krueger F, et al.
Cell Syst
. 2018 Jul;
7(1):63-76.e12.
PMID: 30031774
Pluripotency is accompanied by the erasure of parental epigenetic memory, with naïve pluripotent cells exhibiting global DNA hypomethylation both in vitro and in vivo. Exit from pluripotency and priming for...
10.
Peat J, Smallwood S
Methods Mol Biol
. 2017 Dec;
1708:161-169.
PMID: 29224144
The epigenetic mark 5-methylcytosine confers heritable regulation of gene expression that can be dynamically modulated during transitions in cell fate. With the development of high-throughput sequencing technologies, it is now...