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Genome Biology

Genome Biology is a peer-reviewed scientific journal that focuses on the study of genomics and its impact on biology and medicine. It publishes high-quality research articles, reviews, and methodologies covering a wide range of topics, including genome sequencing, functional genomics, epigenomics, and computational biology. With its interdisciplinary approach, Genome Biology serves as a valuable resource for researchers and professionals interested in understanding the complexities of the genome and its implications in various biological processes.
Details
Abbr. Genome Biol
Start 2000
End Continuing
Frequency Monthly
p-ISSN 1474-7596
e-ISSN 1474-760X
Country United Kingdom
Language English
Specialties Biology
Genetics
Metrics
h-index / Ranks: 202 301
SJR / Ranks: 142 7197
CiteScore / Ranks: 197 25.50
JIF / Ranks: 320 12.3
Recent Articles
1.
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients
Pita-Juarez Y, Karagkouni D, Kalavros N, Melms J, Niezen S, Delorey T, et al.
Genome Biol . 2025 Mar; 26(1):56. PMID: 40087773
Background: The molecular underpinnings of organ dysfunction in severe COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function,...
2.
Integrative phenomics, metabolomics and genomics analysis provides new insights for deciphering the genetic basis of metabolism in polished rice
Feng H, Li Y, Dai G, Yang Z, Song J, Lu B, et al.
Genome Biol . 2025 Mar; 26(1):55. PMID: 40075492
Background: Metabolomics is one of the most widely used omics tools for deciphering the functional networks of the metabolites for crop improvement. However, it is technically demanding and costly. Results:...
3.
mRNA mA regulates gene expression via H3K4me3 shift in 5' UTR
Yang Y, Huang Y, Wang T, Li S, Jiang J, Chen S, et al.
Genome Biol . 2025 Mar; 26(1):54. PMID: 40075435
Background: N-methyladenosine (mA) is a prevalent and conserved RNA modification in eukaryotes. While its roles in the 3' untranslated regions (3' UTR) are well-studied, its role in the 5' UTR...
4.
Single-cell RNA-seq data have prevalent blood contamination but can be rescued by Originator, a computational tool separating single-cell RNA-seq by genetic and contextual information
Unjitwattana T, Huang Q, Yang Y, Tao L, Yang Y, Zhou M, et al.
Genome Biol . 2025 Mar; 26(1):52. PMID: 40069819
Single-cell RNA sequencing (scRNA-seq) data from complex human tissues have prevalent blood cell contamination during the sample preparation process. They may also comprise cells of different genetic makeups. We propose...
5.
Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing
Wang M, Fu P, Chen Z, Wang X, Ma H, Zhang X, et al.
Genome Biol . 2025 Mar; 26(1):53. PMID: 40069752
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging. Here, we present a CRISPR-based homologous recombination-mediated rearrangement...
6.
Precise engineering of gene expression by editing plasticity
Qiu Y, Liu L, Yan J, Xiang X, Wang S, Luo Y, et al.
Genome Biol . 2025 Mar; 26(1):51. PMID: 40065399
Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for...
7.
Trans-ancestral rare variant association study with machine learning-based phenotyping for metabolic dysfunction-associated steatotic liver disease
Chen R, Petrazzini B, Duffy A, Rocheleau G, Jordan D, Bansal M, et al.
Genome Biol . 2025 Mar; 26(1):50. PMID: 40065360
Background: Genome-wide association studies (GWAS) have identified common variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, rare coding variant studies have been limited by phenotyping challenges and small...
8.
DAGIP: alleviating cell-free DNA sequencing biases with optimal transport
Passemiers A, Tuveri S, Jatsenko T, Vanderstichele A, Busschaert P, Coosemans A, et al.
Genome Biol . 2025 Mar; 26(1):49. PMID: 40055826
Cell-free DNA (cfDNA) is a rich source of biomarkers for various pathophysiological conditions. Preanalytical variables, such as the library preparation protocol or sequencing platform, are major confounders of cfDNA analysis....
9.
Genome assembly of the maize B chromosome provides insight into its epigenetic characteristics and effects on the host genome
Liu Q, Liu Y, Yi C, Gao Z, Zhang Z, Zhu C, et al.
Genome Biol . 2025 Mar; 26(1):47. PMID: 40050975
Background: B chromosomes contribute to the genetic variation in numerous eukaryotes. Yet their genetic and epigenetic characteristics, as well as their effects on the host genome remain poorly understood. Results:...
10.
Ultra-sensitive detection of transposon insertions across multiple families by transposable element display sequencing
Vendrell-Mir P, Leduque B, Quadrana L
Genome Biol . 2025 Mar; 26(1):48. PMID: 40050910
Background: Mobilization of transposable elements (TEs) can generate large effect mutations. However, due to the difficulty of detecting new TE insertions in genomes and the typically rare occurrence of transposition,...