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Jeremy Allegood

Explore the profile of Jeremy Allegood including associated specialties, affiliations and a list of published articles. Areas
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Articles 44
Citations 1891
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Recent Articles
1.
Montefusco D, Jamil M, Canals D, Saligrama S, Yue Y, Allegood J, et al.
Cell Rep . 2024 Dec; 43(12):115054. PMID: 39661520
SPTLC3, an inducible subunit of the serine palmitoyltransferase (SPT) complex, causes production of alternative sphingoid bases, including a 16-carbon dihydrosphingosine, whose biological function is only beginning to emerge. High-fat feeding...
2.
Kovilakath A, Mauro A, Valentine Y, Raucci F, Jamil M, Carter C, et al.
Circulation . 2024 Apr; 150(8):622-641. PMID: 38660786
Background: Dysregulated metabolism of bioactive sphingolipids, including ceramides and sphingosine-1-phosphate, has been implicated in cardiovascular disease, although the specific species, disease contexts, and cellular roles are not completely understood. Sphingolipids...
3.
Liss K, Mousa M, Bucha S, Lutkewitte A, Allegood J, Cowart L, et al.
Sci Rep . 2024 Feb; 14(1):3584. PMID: 38351300
Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common cause for liver transplantation in many parts of the world. Moreover, the prevalence of MASLD...
4.
Chen Q, Kovilakath A, Allegood J, Thompson J, Hu Y, Cowart L, et al.
Biochim Biophys Acta Mol Cell Biol Lipids . 2023 Jul; 1868(10):159366. PMID: 37473835
The endoplasmic reticulum (ER) plays a key role in the regulation of protein folding, lipid synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis. ER stress (ER...
5.
Tharakan A, Kumar A, Allegood J, Cowart L, Conrad D, Martin R
Allergy . 2023 Jul; 78(11):3014-3016. PMID: 37408337
No abstract available.
6.
Montefusco D, Jamil M, Maczis M, Schroeder W, Levi M, Ranjit S, et al.
Mol Metab . 2022 Jun; 62:101523. PMID: 35671973
Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism...
7.
Montefusco D, Lambert J, Anderson A, Allegood J, Cowart L
Methods Mol Biol . 2022 Feb; 2455:279-303. PMID: 35213002
The relationship between sphingolipid levels and NAFLD pathology has been recognized for some time. Numerous studies using pharmacological and genetic approaches in vitro and in animal models of NAFLD have...
8.
Mondal K, Takahashi H, Cole 2nd J, Del Mar N, Li C, Stephenson D, et al.
Mol Neurobiol . 2021 Aug; 58(11):5564-5580. PMID: 34365584
Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration leading to various pathological complications such as motor and sensory (visual) deficits, cognitive impairment, and depression. N-3 polyunsaturated fatty acid (n-3 PUFA)...
9.
Boyd A, Allegood J, Lima S
J Vis Exp . 2021 May; (170). PMID: 33999023
Sphingolipids are cellular components that have well-established roles in human metabolism and disease. Mass spectrometry can be used to determine whether sphingolipids are altered in a disease and investigate whether...
10.
Rohrbach T, Boyd A, Grizzard P, Spiegel S, Allegood J, Lima S
J Lipid Res . 2020 Apr; 61(6):953-967. PMID: 32341007
MS-assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the...