Sarah J Mitchell
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Explore the profile of Sarah J Mitchell including associated specialties, affiliations and a list of published articles.
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90
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Recent Articles
1.
Kiesworo K, Agius T, MacArthur M, Lambelet M, Lyon A, Zhang J, et al.
iScience
. 2025 Jan;
28(1):111656.
PMID: 39868046
Aging is accompanied by a decline in neovascularization potential and increased susceptibility to ischemic injury. Here, we confirm the age-related impaired neovascularization following ischemic leg injury and impaired angiogenesis. The...
2.
Lyon A, Agius T, MacArthur M, Kiesworo K, Stavart L, Allagnat F, et al.
iScience
. 2025 Jan;
27(12):111256.
PMID: 39759002
One-week protein restriction (PR) limits ischemia-reperfusion (IR) damages and improves metabolic fitness. Similarly, longer-term calory restriction results in increased lifespan, partly via reduced insulin-like growth factor (IGF)-1. However, the influence...
3.
Kip P, Sluiter T, MacArthur M, Tao M, Kruit N, Mitchell S, et al.
Nat Commun
. 2024 Nov;
15(1):9652.
PMID: 39511181
Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR...
4.
Winardi K, Mach J, McKay M, Molloy M, Mitchell S, MacArthur M, et al.
Aging Cell
. 2024 Oct;
24(1):e14357.
PMID: 39462793
Polypharmacy (use of ≥5 concurrent medications) is highly prevalent among older adults to manage chronic diseases and is linked to adverse geriatric outcomes, including physical and cognitive functional impairments, falls,...
5.
Koppold D, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar A, et al.
Cell Metab
. 2024 Jul;
36(8):1779-1794.e4.
PMID: 39059384
Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology is lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers and clinicians standardized definitions of various...
6.
Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle
Mann C, MacArthur M, Zhang J, Gong S, AbuSalim J, Hunter C, et al.
bioRxiv
. 2024 Jul;
PMID: 39005372
Dietary restriction of the sulfur-containing amino acids methionine and cysteine (SAAR) improves body composition, enhances insulin sensitivity, and extends lifespan; benefits seen also with endurance exercise. Yet, the impact of...
7.
Kane A, Chellappa K, Schultz M, Arnold M, Li J, Amorim J, et al.
bioRxiv
. 2024 Jul;
PMID: 38979132
Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging,...
8.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.
9.
Agius T, Emsley R, Lyon A, MacArthur M, Kiesworo K, Faivre A, et al.
Nat Commun
. 2024 Feb;
15(1):1073.
PMID: 38316771
Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway...
10.
Griffin P, Kane A, Trapp A, Li J, Arnold M, Poganik J, et al.
Nat Aging
. 2024 Jan;
4(2):261-274.
PMID: 38200273
Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely used aging biomarkers, but conventional methods for applying them are expensive and laborious. Here we develop...