Alice E Kane
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Explore the profile of Alice E Kane including associated specialties, affiliations and a list of published articles.
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43
Citations
1456
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Recent Articles
1.
Zhu D, Wu J, Griffin P, Samuelson B, Sinclair D, Kane A
bioRxiv
. 2025 Feb;
PMID: 39896479
Frailty is an age-related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA...
2.
Zhu D, Arnold M, Samuelson B, Wu J, Mueller A, Sinclair D, et al.
Biol Sex Differ
. 2024 Nov;
15(1):89.
PMID: 39482778
Background: Aging is a complex process that involves all tissues in an organism and shows sex dimorphism. While transcriptional changes in aging have been well characterized, the majority of studies...
3.
Bartolomucci A, Kane A, Gaydosh L, Razzoli M, McCoy B, Ehninger D, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Aug;
79(9).
PMID: 39126297
For centuries, aging was considered inevitable and immutable. Geroscience provides the conceptual framework to shift this focus toward a new view that regards aging as an active biological process, and...
4.
Kane A, Chellappa K, Schultz M, Arnold M, Li J, Amorim J, et al.
bioRxiv
. 2024 Jul;
PMID: 38979132
Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging,...
5.
Mishra M, Wu J, Kane A, Howlett S
Cell Metab
. 2024 Apr;
36(5):893-911.
PMID: 38614092
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to...
6.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.
7.
Griffin P, Kane A, Trapp A, Li J, Arnold M, Poganik J, et al.
Nat Aging
. 2024 Jan;
4(2):261-274.
PMID: 38200273
Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely used aging biomarkers, but conventional methods for applying them are expensive and laborious. Here we develop...
8.
Mitchell S, MacArthur M, Kane A
Br J Clin Pharmacol
. 2023 Sep;
91(1):5-7.
PMID: 37675638
Preclinical models have been the backbone of translational research for more than a century. Rats and mice are critical models in the preliminary stages of drug testing, both for determining...
9.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2023 Jan;
186(2):305-326.e27.
PMID: 36638792
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of...
10.
Alaghband Y, Klein P, Kramar E, Cranston M, Perry B, Shelerud L, et al.
Cell Mol Life Sci
. 2023 Jan;
80(1):29.
PMID: 36607431
Technological advancements have facilitated the implementation of realistic, terrestrial-based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe central nervous system functionality. This work expands considerably on prior,...