Michael R MacArthur
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Explore the profile of Michael R MacArthur including associated specialties, affiliations and a list of published articles.
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39
Citations
591
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Recent Articles
1.
Lee W, Weilandt D, Liang L, MacArthur M, Jaiswal N, Ong O, et al.
Cell Metab
. 2025 Jan;
37(3):758-771.e8.
PMID: 39889702
Lactate is among the highest flux circulating metabolites. It is made by glycolysis and cleared by both tricarboxylic acid (TCA) cycle oxidation and gluconeogenesis. Severe lactate elevations are life-threatening, and...
2.
Kiesworo K, Agius T, MacArthur M, Lambelet M, Lyon A, Zhang J, et al.
iScience
. 2025 Jan;
28(1):111656.
PMID: 39868046
Aging is accompanied by a decline in neovascularization potential and increased susceptibility to ischemic injury. Here, we confirm the age-related impaired neovascularization following ischemic leg injury and impaired angiogenesis. The...
3.
Lyon A, Agius T, MacArthur M, Kiesworo K, Stavart L, Allagnat F, et al.
iScience
. 2025 Jan;
27(12):111256.
PMID: 39759002
One-week protein restriction (PR) limits ischemia-reperfusion (IR) damages and improves metabolic fitness. Similarly, longer-term calory restriction results in increased lifespan, partly via reduced insulin-like growth factor (IGF)-1. However, the influence...
4.
Kip P, Sluiter T, MacArthur M, Tao M, Kruit N, Mitchell S, et al.
Nat Commun
. 2024 Nov;
15(1):9652.
PMID: 39511181
Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR...
5.
Winardi K, Mach J, McKay M, Molloy M, Mitchell S, MacArthur M, et al.
Aging Cell
. 2024 Oct;
24(1):e14357.
PMID: 39462793
Polypharmacy (use of ≥5 concurrent medications) is highly prevalent among older adults to manage chronic diseases and is linked to adverse geriatric outcomes, including physical and cognitive functional impairments, falls,...
6.
Altintas O, MacArthur M
Front Aging
. 2024 Sep;
5:1447370.
PMID: 39319345
The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also...
7.
Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle
Mann C, MacArthur M, Zhang J, Gong S, AbuSalim J, Hunter C, et al.
bioRxiv
. 2024 Jul;
PMID: 39005372
Dietary restriction of the sulfur-containing amino acids methionine and cysteine (SAAR) improves body composition, enhances insulin sensitivity, and extends lifespan; benefits seen also with endurance exercise. Yet, the impact of...
8.
Moliere A, Park J, Goyala A, Vayndorf E, Zhang B, Hsiung K, et al.
Geroscience
. 2024 Jun;
46(5):5015-5036.
PMID: 38900346
Little is known about the possibility of reversing age-related biological changes when they have already occurred. To explore this, we have characterized the effects of reducing insulin/IGF-1 signaling (IIS) during...
9.
Trautman M, Green C, MacArthur M, Chaiyakul K, Alam Y, Yeh C, et al.
bioRxiv
. 2024 Jun;
PMID: 38895446
The amino acid composition of the diet has recently emerged as a critical regulator of metabolic health. Consumption of the branched-chain amino acid isoleucine is positively correlated with body mass...
10.
Doleckova I, Vidovic T, Jandova L, Gretzmeier C, Navarini A, MacArthur M, et al.
J Invest Dermatol
. 2024 Mar;
144(9):2103-2107.e2.
PMID: 38490440
No abstract available.