David A Sinclair
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Explore the profile of David A Sinclair including associated specialties, affiliations and a list of published articles.
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203
Citations
28995
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Recent Articles
1.
Drake S, Mohammadnia A, Zaman A, Gianfelice C, Heale K, Groh A, et al.
Cell Rep
. 2025 Feb;
44(2):115298.
PMID: 39937646
In multiple sclerosis (MS), inflammation of the central nervous system results in demyelination, neuroaxonal injury, and cell death. However, the molecular signals responsible for injury and cell death in neurons...
2.
Zhu D, Wu J, Griffin P, Samuelson B, Sinclair D, Kane A
bioRxiv
. 2025 Feb;
PMID: 39896479
Frailty is an age-related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA...
3.
4.
Zhu D, Arnold M, Samuelson B, Wu J, Mueller A, Sinclair D, et al.
Biol Sex Differ
. 2024 Nov;
15(1):89.
PMID: 39482778
Background: Aging is a complex process that involves all tissues in an organism and shows sex dimorphism. While transcriptional changes in aging have been well characterized, the majority of studies...
5.
Lyu Y, Fu Q, Wilczok D, Ying K, King A, Antebi A, et al.
Aging (Albany NY)
. 2024 Oct;
16(20):12955-12976.
PMID: 39418098
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We,...
6.
Ho W, Marinova M, Listijono D, Bertoldo M, Richani D, Kim L, et al.
EMBO Mol Med
. 2024 Aug;
16(10):2583-2618.
PMID: 39169162
Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed....
7.
Kane A, Chellappa K, Schultz M, Arnold M, Li J, Amorim J, et al.
bioRxiv
. 2024 Jul;
PMID: 38979132
Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging,...
8.
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, et al.
PLoS One
. 2024 Jun;
19(6):e0305277.
PMID: 38843127
[This corrects the article DOI: 10.1371/journal.pone.0002020.].
9.
Pernomian L, Waigi E, Nguyen V, Mohammed A, da Costa T, Fontes M, et al.
bioRxiv
. 2024 Jun;
PMID: 38826452
Background: Small artery remodeling and endothelial dysfunction are hallmarks of hypertension. Growing evidence supports a likely causal association between cardiovascular diseases and the presence of endothelial-to-mesenchymal transition (EndMT), a cellular...
10.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.