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Rafael de Cabo

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Articles 346
Citations 24344
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Recent Articles
1.
Rogina B, Anderson R, LeBrasseur N, Curan S, Yousefzadeh M, Ghosh B, et al.
J Gerontol A Biol Sci Med Sci . 2025 Feb; PMID: 39932386
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic...
2.
Sanchez-Mendoza L, Gonzalez-Reyes J, Rodriguez-Lopez S, Calvo-Rubio M, Calero-Rodriguez P, de Cabo R, et al.
Mitochondrion . 2025 Jan; 81:102004. PMID: 39793940
Cytochrome b reductase 3 (CYB5R3) overexpression upregulates mitochondrial biogenesis, function, and abundance in skeletal muscle and kidneys, and mimics some of the salutary effects of calorie restriction, with the most...
3.
Dote-Montero M, Clavero-Jimeno A, Merchan-Ramirez E, Oses M, Echarte J, Camacho-Cardenosa A, et al.
Nat Med . 2025 Jan; 31(2):524-533. PMID: 39775037
The optimal eating window for time-restricted eating (TRE) remains unclear, particularly its impact on visceral adipose tissue (VAT), which is associated with cardiometabolic morbidity and mortality. We investigated the effects...
4.
Martinez-Romero J, Fernandez M, Bernier M, Price N, Mueller W, Candia J, et al.
Nat Aging . 2024 Oct; 4(12):1882-1896. PMID: 39424993
Biological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging...
5.
Lyu Y, Fu Q, Wilczok D, Ying K, King A, Antebi A, et al.
Aging (Albany NY) . 2024 Oct; 16(20):12955-12976. PMID: 39418098
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We,...
6.
Calvo-Rubio M, Garcia-Domiguez E, Tamayo-Torres E, Soto-Rodriguez S, Olaso-Gonzalez G, Ferrucci L, et al.
Free Radic Biol Med . 2024 Sep; 225:247-254. PMID: 39343184
Physical exercise is well-established as beneficial for health. With the 20th-century epidemiological transition, promoting healthy habits like exercise has become crucial for preventing chronic diseases. Stress can yield adaptive long-term...
7.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol . 2024 Aug; 26(9):1571-1584. PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
8.
Occean J, Yang N, Sun Y, Dawkins M, Munk R, Belair C, et al.
Nat Commun . 2024 Jul; 15(1):6357. PMID: 39069555
DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has...
9.
Sanchez-Mendoza L, Perez-Sanchez C, Garcia-Caballero C, Perez-Rodriguez M, Calero-Rodriguez P, Vellon-Garcia B, et al.
Free Radic Biol Med . 2024 Jul; 223:69-86. PMID: 39069267
There is a pressing need to develop new strategies for enhancing health in the elderly and preventing the rise in age-related diseases. Calorie restriction without malnutrition (CR) stands among the...
10.
Koppold D, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar A, et al.
Cell Metab . 2024 Jul; 36(8):1779-1794.e4. PMID: 39059384
Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology is lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers and clinicians standardized definitions of various...