James R Mitchell
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Explore the profile of James R Mitchell including associated specialties, affiliations and a list of published articles.
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97
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5028
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Recent Articles
1.
Kip P, Sluiter T, MacArthur M, Tao M, Kruit N, Mitchell S, et al.
Nat Commun
. 2024 Nov;
15(1):9652.
PMID: 39511181
Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR...
2.
Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle
Mann C, MacArthur M, Zhang J, Gong S, AbuSalim J, Hunter C, et al.
bioRxiv
. 2024 Jul;
PMID: 39005372
Dietary restriction of the sulfur-containing amino acids methionine and cysteine (SAAR) improves body composition, enhances insulin sensitivity, and extends lifespan; benefits seen also with endurance exercise. Yet, the impact of...
3.
Miller R, Harrison D, Cortopassi G, Dehghan I, Fernandez E, Garratt M, et al.
Geroscience
. 2024 Jul;
PMID: 39004654
No abstract available.
4.
Miller R, Harrison D, Cortopassi G, Dehghan I, Fernandez E, Garratt M, et al.
Geroscience
. 2024 May;
46(5):4657-4670.
PMID: 38753230
Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol (DNP), hydralazine (HYD), nebivolol (NEBI), 16α-hydroxyestriol (OH_Est), and sodium thiosulfate (THIO), and...
5.
Griffin P, Kane A, Trapp A, Li J, Arnold M, Poganik J, et al.
Nat Aging
. 2024 Jan;
4(2):261-274.
PMID: 38200273
Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely used aging biomarkers, but conventional methods for applying them are expensive and laborious. Here we develop...
6.
Harrison D, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, et al.
Geroscience
. 2023 Dec;
46(1):795-816.
PMID: 38041783
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test), while...
7.
Kip P, Sluiter T, MacArthur M, Tao M, Jung J, Mitchell S, et al.
bioRxiv
. 2023 Nov;
PMID: 37961405
Short-term preoperative methionine restriction (MetR) shows promise as a translatable strategy to modulate the body's response to surgical injury. Its application, however, to improve post-interventional vascular remodeling remains underexplored. Here,...
8.
Kiesworo K, MacArthur M, Kip P, Agius T, Macabrey D, Lambelet M, et al.
JVS Vasc Sci
. 2023 Feb;
4:100095.
PMID: 36852171
Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. However,...
9.
MacArthur M, Mitchell S, Chadaideh K, Trevino-Villarreal J, Jung J, Kalafut K, et al.
Cell Rep
. 2022 Aug;
40(7):111187.
PMID: 35977507
Dietary protein restriction (PR) has rapid effects on metabolism including improved glucose and lipid homeostasis, via multiple mechanisms. Here, we investigate responses of fecal microbiome, hepatic transcriptome, and hepatic metabolome...
10.
Schrotter S, Yuskaitis C, MacArthur M, Mitchell S, Hosios A, Osipovich M, et al.
Cell Rep
. 2022 May;
39(7):110824.
PMID: 35584673
The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver...