Ruth S Slack
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Explore the profile of Ruth S Slack including associated specialties, affiliations and a list of published articles.
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113
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7527
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Recent Articles
1.
Baindoor S, Gibriel H, Veno M, Su J, Morrissey E, Jirstrom E, et al.
Dis Model Mech
. 2024 Nov;
17(11).
PMID: 39552337
Transfer RNA-derived small RNAs (tsRNAs) - categorized as tRNA-derived fragments (tRFs), tRNA-derived stress-induced RNAs (tiRNAs) and internal tRF (itRF) - are small non-coding RNAs that participate in various cellular processes...
2.
Iqbal M, Bilen M, Liu Y, Jabre V, Fong B, Chakroun I, et al.
Aging Cell
. 2024 May;
23(7):e14165.
PMID: 38757355
Impaired mitochondrial function is a hallmark of aging and a major contributor to neurodegenerative diseases. We have shown that disrupted mitochondrial dynamics typically found in aging alters the fate of...
3.
Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, et al.
EMBO Rep
. 2024 Mar;
25(3):1256-1281.
PMID: 38429579
The plant homeodomain zinc-finger protein, PHF6, is a transcriptional regulator, and PHF6 germline mutations cause the X-linked intellectual disability (XLID) Börjeson-Forssman-Lehmann syndrome (BFLS). The mechanisms by which PHF6 regulates transcription...
4.
Gonzalez Y, Kamkar F, Jafar-Nejad P, Wang S, Qu D, Alvarez L, et al.
BMC Biol
. 2023 Nov;
21(1):240.
PMID: 37907898
Background: PFTK1/Eip63E is a member of the cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E expresses primarily in postnatal and adult nervous system...
5.
Liu Y, Bilen M, McNicoll M, Harris R, Fong B, Iqbal M, et al.
Cell Death Dis
. 2023 Feb;
14(2):138.
PMID: 36801910
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, which is one of the sites where neural stem cells reside and new neurons are born, exhibits...
6.
Fong B, Chakroun I, Iqbal M, Paul S, Bastasic J, ONeil D, et al.
Cell Rep
. 2022 Nov;
41(5):111578.
PMID: 36323247
Long-term maintenance of the adult neurogenic niche depends on proper regulation of entry and exit from quiescence. Neural stem cell (NSC) transition from quiescence to activation is a complex process...
7.
Lithopoulos M, Toussay X, Zhong S, Xu L, Mustafa S, Ouellette J, et al.
J Clin Invest
. 2022 Sep;
132(22).
PMID: 36136598
Preterm birth is the leading cause of death in children under 5 years of age. Premature infants who receive life-saving oxygen therapy often develop bronchopulmonary dysplasia (BPD), a chronic lung...
8.
Iqbal M, Fong B, Slack R
Methods Mol Biol
. 2022 Jul;
2515:117-127.
PMID: 35776349
Adult neural stem and progenitor cells reside in the neurogenic niche of the adult brain and have tremendous potential in regenerative medicine. Compelling evidence suggests that adult neurogenesis plays an...
9.
Im D, Joselin A, Svoboda D, Takano T, Rousseaux M, Callaghan S, et al.
BMC Biol
. 2022 May;
20(1):115.
PMID: 35581583
Background: Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth...
10.
Patten D, McGuirk S, Anilkumar U, Antoun G, Gandhi K, Parmar G, et al.
Biochim Biophys Acta Mol Cell Res
. 2020 Sep;
1868(1):118854.
PMID: 32926942
Mitochondria are highly dynamic organelles. Alterations in mitochondrial dynamics are causal or are linked to numerous neurodegenerative, neuromuscular, and metabolic diseases. It is generally thought that cells with altered mitochondrial...