Maxime W C Rousseaux
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Explore the profile of Maxime W C Rousseaux including associated specialties, affiliations and a list of published articles.
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32
Citations
1058
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Recent Articles
1.
Kalia L, Asis A, Arbour N, Bar-Or A, Bove R, Di Luca D, et al.
Nat Rev Neurol
. 2024 Oct;
20(12):724-737.
PMID: 39375563
The development of disease-modifying therapies (DMTs) for neurological disorders is an important goal in modern neurology, and the associated challenges are similar in many chronic neurological conditions. Major advances have...
2.
Parmasad J, Ricke K, Nguyen B, Stykel M, Buchner-Duby B, Bruce A, et al.
Cell Death Dis
. 2024 Apr;
15(4):246.
PMID: 38575601
Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow...
3.
Geertsma H, Fisk Z, Sauline L, Prigent A, Kurgat K, Callaghan S, et al.
NPJ Parkinsons Dis
. 2024 Mar;
10(1):65.
PMID: 38504090
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. Lewy pathology contains aggregated α-synuclein (αSyn), a protein encoded by...
4.
van Bruggen R, Patel Z, Wang M, Suk T, Rousseaux M, Tan Q
eNeuro
. 2023 Sep;
10(10).
PMID: 37775311
Cajal-Retzius (CR) cells are transient neurons with long-lasting effects on the architecture and circuitry of the neocortex and hippocampus. Contrary to the prevailing assumption that CR cells completely disappear in...
5.
Suk T, Nguyen T, Fisk Z, Mitkovski M, Geertsma H, Parmasad J, et al.
iScience
. 2023 Apr;
26(4):106350.
PMID: 37009224
SUMOylation is an evolutionarily conserved eukaryotic posttranslational protein modification with broad biological relevance. Differentiating between the major small ubiquitin-like modifier (SUMO) paralogs and uncovering paralog-specific functions has long been very...
6.
Geertsma H, Ricke K, Rousseaux M
Methods Mol Biol
. 2022 Jul;
2515:151-169.
PMID: 35776351
Neuron death is a key feature of neurological disorders like Alzheimer's or Parkinson's disease (PD). As a result, analysis of neurodegeneration is often considered a central experiment in the postmortem...
7.
Chen L, Nagaraja C, Daniels S, Fisk Z, Dvorak R, Meyerdirk L, et al.
Elife
. 2022 Jul;
11.
PMID: 35775627
The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the pathogenesis of Parkinson's disease (PD). In PD, the amygdala is prone to develop insoluble αSyn aggregates, and...
8.
Im D, Joselin A, Svoboda D, Takano T, Rousseaux M, Callaghan S, et al.
BMC Biol
. 2022 May;
20(1):115.
PMID: 35581583
Background: Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth...
9.
Geertsma H, Suk T, Ricke K, Horsthuis K, Parmasad J, Fisk Z, et al.
Hum Mol Genet
. 2022 Feb;
31(21):3613-3628.
PMID: 35179202
A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson's disease (PD). However, this question has been difficult to address as controlling...
10.
Lee W, Lavery L, Rousseaux M, Rutledge E, Jang Y, Wan Y, et al.
EMBO J
. 2021 Mar;
40(7):e106106.
PMID: 33709453
A critical question in neurodegeneration is why the accumulation of disease-driving proteins causes selective neuronal loss despite their brain-wide expression. In Spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded Ataxin-1...