Jason G MacLaurin
Overview
Explore the profile of Jason G MacLaurin including associated specialties, affiliations and a list of published articles.
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12
Citations
1270
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Recent Articles
1.
Khacho M, Clark A, Svoboda D, MacLaurin J, Lagace D, Park D, et al.
Hum Mol Genet
. 2017 Jun;
26(17):3327-3341.
PMID: 28595361
Mitochondrial dysfunction is a common feature of many genetic disorders that target the brain and cognition. However, the exact role these organelles play in the etiology of such disorders is...
2.
Khacho M, Clark A, Svoboda D, Azzi J, MacLaurin J, Meghaizel C, et al.
Cell Stem Cell
. 2016 May;
19(2):232-247.
PMID: 27237737
Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in tissue development and homeostasis, its role in...
3.
Patten D, Wong J, Khacho M, Soubannier V, Mailloux R, Pilon-Larose K, et al.
EMBO J
. 2014 Oct;
33(22):2676-91.
PMID: 25298396
Cristae, the organized invaginations of the mitochondrial inner membrane, respond structurally to the energetic demands of the cell. The mechanism by which these dynamic changes are regulated and the consequences...
4.
Khacho M, Tarabay M, Patten D, Khacho P, MacLaurin J, Guadagno J, et al.
Nat Commun
. 2014 Apr;
5:3550.
PMID: 24686499
Sustained cellular function and viability of high-energy demanding post-mitotic cells rely on the continuous supply of ATP. The utilization of mitochondrial oxidative phosphorylation for efficient ATP generation is a function...
5.
Jahani-Asl A, Pilon-Larose K, Xu W, MacLaurin J, Park D, McBride H, et al.
J Biol Chem
. 2010 Nov;
286(6):4772-82.
PMID: 21041314
Mitochondrial dynamics have been extensively studied in the context of classical cell death models involving Bax-mediated cytochrome c release. Excitotoxic neuronal loss is a non-classical death signaling pathway that occurs...
6.
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate
Vanderluit J, Wylie C, McClellan K, Ghanem N, Fortin A, Callaghan S, et al.
J Cell Biol
. 2007 Jun;
178(1):129-39.
PMID: 17591923
The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. As p107-deficient mice exhibit enhanced levels of Hes1, we questioned whether p107 regulates neural...
7.
Jahani-Asl A, Cheung E, Neuspiel M, MacLaurin J, Fortin A, Park D, et al.
J Biol Chem
. 2007 Jun;
282(33):23788-98.
PMID: 17537722
Of the GTPases involved in the regulation of the fusion machinery, mitofusin 2 (Mfn2) plays an important role in the nervous system as point mutations of this isoform are associated...
8.
Cheung E, Joza N, Steenaart N, McClellan K, Neuspiel M, McNamara S, et al.
EMBO J
. 2006 Aug;
25(17):4061-73.
PMID: 16917506
The mitochondrial protein apoptosis-inducing factor (AIF) translocates to the nucleus and induces apoptosis. Recent studies, however, have indicated the importance of AIF for survival in mitochondria. In the absence of...
9.
Cregan S, Arbour N, MacLaurin J, Callaghan S, Fortin A, Cheung E, et al.
J Neurosci
. 2004 Nov;
24(44):10003-12.
PMID: 15525786
The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance of p53 in neuronal injury,...
10.
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1
Fortin A, MacLaurin J, Arbour N, Cregan S, Kushwaha N, Callaghan S, et al.
J Biol Chem
. 2004 Apr;
279(27):28706-14.
PMID: 15105421
The p53 tumor suppressor gene is believed to play an important role in neuronal cell death in acute neurological disease and in neurodegeneration. The p53 signaling cascade is complex, and...