Disease Models & Mechanisms
Overview
Disease Models & Mechanisms is a peer-reviewed scientific journal that focuses on the use of animal models to study human diseases. It covers a wide range of topics, including genetics, cell biology, and physiology, providing valuable insights into disease mechanisms and potential therapeutic approaches. The journal aims to bridge the gap between basic research and clinical applications, making it an essential resource for researchers and clinicians in the field of disease modeling.
Details
Details
Abbr.
Dis Model Mech
Start
2008
End
Continuing
Frequency
Six no. a year, 2011-
p-ISSN
1754-8403
e-ISSN
1754-8411
Country
United Kingdom
Language
English
Specialty
General Medicine
Metrics
Metrics
h-index / Ranks: 2769
107
SJR / Ranks: 2287
1361
CiteScore / Ranks: 2534
7.50
JIF / Ranks: 2027
4.3
Recent Articles
1.
Perez-Lopez D, Burke M, Hakim C, Teixeira J, Han J, Yue Y, et al.
Dis Model Mech
. 2025 Mar;
18(3).
PMID: 40084478
To establish a minimally invasive approach to studying body-wide muscle inflammation in the canine Duchenne muscular dystrophy (DMD) model, we evaluated 13 cytokines/chemokines in frozen sera from 90 affected (239...
2.
Giese A, Parker A, Rehman S, Brown S, Riazuddin S, Vander Kooi C, et al.
Dis Model Mech
. 2025 Mar;
PMID: 40083274
Humans and mice with mutations in genes encoding CIB2 and whirlin (WHRN) are deaf. We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of...
3.
Briscoe J, Franklin C, Gorelick D, Patton E, Way M
Dis Model Mech
. 2025 Mar;
18(3).
PMID: 40079458
No abstract available.
4.
5.
Klem J, Schwantes-An T, Abreu M, Suttie M, Gray R, Vo H, et al.
Dis Model Mech
. 2025 Mar;
PMID: 40067253
Fetal Alcohol Spectrum Disorders (FASD) describe ethanol-induced developmental defects including craniofacial malformations. While ethanol-sensitive genetic mutations contribute to facial malformations, the impacted cellular mechanisms remain unknown. Bmp signaling is a...
6.
Charles-Nino C, Desai G, Koroneos N, Hamed M, Jain N, Lopes W, et al.
Dis Model Mech
. 2025 Mar;
PMID: 40067245
Cryptococcus deneoformans (Cd) and C. neoformans (Cn) differ in geographic prevalence and dermatotropism, with Cd strains more commonly isolated from temperate regions and skin infections. Rising global temperatures prompt concerns...
7.
McDaniel Mims B, Furr K, Enriquez J, Grisham M
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 40019007
The transplantation of allogeneic hematopoietic stem cells is a potentially curative treatment for hematological malignancies, inherited blood disorders and immune deficiencies. Unfortunately, 30-50% of patients receiving allogeneic hematopoietic stem cells...
8.
Ling S, Dexter A, Race A, Sharma S, Hamm G, Polanska U, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 40019006
The PI3K-mTOR-AKT pathway regulates tumour proliferation, gene expression and metabolism, but pathway inhibition induces heterogeneous feedback reactivation, limiting anti-tumour responses. Measuring heterogeneity of pathway inhibition in tissues using protein biomarker...
9.
Montgomery C, Salinas L, Cox G, Adcock L, Chang T, Figueroa F, et al.
Dis Model Mech
. 2025 Feb;
PMID: 40017373
Friedreich's ataxia, a recessive disorder caused by a mutation in the frataxin (Fxn) gene, has few mouse models that demonstrate a progressive behavioral decline paralleling patients. A mouse model of...
10.
Varady A, Grissenberger S, Wenninger-Weinzierl A, Poplimont H, Sturtzel C, Schmitner N, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 40014051
Owing to their high efficacy, antimitotic chemotherapeutics are the mainstay for most cancer treatments. However, these drugs do not discriminate between tumor and healthy cells, thus show dose-limiting toxicity and...