Ronald T Raines
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Explore the profile of Ronald T Raines including associated specialties, affiliations and a list of published articles.
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348
Citations
9052
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Recent Articles
1.
Araiza-Olivera D, Prudnikova T, Uribe-Alvarez C, Cai K, Franco-Barraza J, Dones J, et al.
Mol Cancer Res
. 2025 Jan;
PMID: 39836438
Breast cancers of the IntClust-2 type, characterized by amplification of a small portion of chromosome 11, have a median survival of only five years. Several cancer-relevant genes occupy this portion...
2.
Giancola J, Raines R
Chem Commun (Camb)
. 2024 Nov;
60(100):15019-15022.
PMID: 39601427
Precision genetic medicine enlists antisense oligonucleotides (ASOs) to bind to nucleic acid targets important for human disease. Peptide nucleic acids (PNAs) have many desirable attributes as ASOs but lack cellular...
3.
Yammine K, Li R, Borgula I, Abularach S, DiChiara A, Raines R, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2412948121.
PMID: 39503893
Collagens are the foundational component of diverse tissues, including skin, bone, cartilage, and basement membranes, and are the most abundant protein class in animals. The fibrillar collagens are large, complex,...
4.
Yang J, Kojasoy V, Porter G, Raines R
ACS Cent Sci
. 2024 Oct;
10(10):1829-1834.
PMID: 39463835
Proteins have evolved to function in an aqueous environment. Collagen, which provides the bodily scaffold for animals, has a special need to retain its integrity. This need was addressed early...
5.
Gutierrez C, Kassim A, Gutierrez B, Raines R
Bioinformatics
. 2024 Oct;
40(11).
PMID: 39388212
Motivation: Post-translational modifications (PTMs) increase the diversity of the proteome and are vital to organismal life and therapeutic strategies. Deep learning has been used to predict PTM locations. Still, limitations...
6.
Petri Y, Verresen R, Gutierrez C, Kojasoy V, Zhang E, Abularrage N, et al.
Biochemistry
. 2024 Oct;
63(20):2580-2593.
PMID: 39359146
As a traceless, bioreversible modification, the esterification of carboxyl groups in peptides and proteins has the potential to increase their clinical utility. An impediment is the lack of strategies to...
7.
Yang J, Quan Y, Ouyang Y, Tan K, Weber R, Griffin R, et al.
Biomacromolecules
. 2024 Sep;
25(10):6773-6779.
PMID: 39225003
Collagen-mimetic peptides (CMP) have been invaluable tools for understanding the structure and function of collagen, which is the most abundant protein in animals. CMPs have also been developed as probes...
8.
Petri Y, FitzGerald F, Raines R
Bioconjug Chem
. 2024 Aug;
35(9):1300-1308.
PMID: 39206956
Nature utilizes bioreversible post-translational modifications (PTMs) to spatiotemporally diversify protein function. Mimicking Nature's approach, chemists have developed a variety of chemoselective regents for traceless, bioreversible modification of native proteins. These...
9.
Levandowski B, Graham B, Abularrage N, Raines R
J Phys Org Chem
. 2024 Aug;
37(9).
PMID: 39185358
The condensation of 1,3-diketones with hydrazine to access 4-pyrazoles is a well-established synthetic route that travels through a 4-pyrazol-1-ium intermediate. In the route to a 3,5-diphenyl-4-pyrazole containing a cyclobutane spirocycle,...
10.
Park G, Wralstad E, Faginas-Lago N, Qian K, Raines R, Bistoni G, et al.
ACS Cent Sci
. 2024 Jul;
10(7):1415-1422.
PMID: 39071052
Pentametaphosphate is the little studied cyclic pentamer of the metaphosphate ion, [PO] . We show that the doubly protonated form of this pentamer can be selectively dehydrated to provide the...