Chelcie H Eller
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Explore the profile of Chelcie H Eller including associated specialties, affiliations and a list of published articles.
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10
Citations
139
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Recent Articles
1.
Lee T, Checco J, Malcolm T, Eller C, Raines R, Gellman S, et al.
Aust J Chem
. 2023 Oct;
76(8):482-492.
PMID: 37780415
The intrinsic pathway of apoptosis is regulated by the Bcl-2 family of proteins. Inhibition of the anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We...
2.
Eller C, Raines R
ACS Infect Dis
. 2020 Oct;
6(11):3083-3088.
PMID: 33054163
LL-37 is a secretory peptide that has antimicrobial activity. Ribonuclease 1 (RNase 1) is a secretory enzyme that is not cytotoxic. We find that human LL-37 and human RNase 1...
3.
Lomax J, Eller C, Raines R
Biochem J
. 2017 May;
474(13):2219-2233.
PMID: 28495858
Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family is ribonuclease 1 (RNase 1). Understanding the physiological roles of RNase...
4.
Eller C, Chao T, Singarapu K, Ouerfelli O, Yang G, Markley J, et al.
ACS Cent Sci
. 2015 Sep;
1(4):181-190.
PMID: 26405690
Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells,...
5.
Checco J, Lee E, Evangelista M, Sleebs N, Rogers K, Pettikiriarachchi A, et al.
J Am Chem Soc
. 2015 Aug;
137(35):11365-75.
PMID: 26317395
Peptides can be developed as effective antagonists of protein-protein interactions, but conventional peptides (i.e., oligomers of l-α-amino acids) suffer from significant limitations in vivo. Short half-lives due to rapid proteolytic...
6.
Eller C, Yang G, Ouerfelli O, Raines R
Carbohydr Res
. 2014 Aug;
397:1-6.
PMID: 25163606
Globo-series glycans are human cell-surface carbohydrates that include stem-cell marker SSEA-4 and cancer-cell antigen Globo H. These two hexasaccharides differ only in their terminal saccharide: N-acetylneuraminic acid in SSEA-4 and...
7.
Eller C, Lomax J, Raines R
J Biol Chem
. 2014 Aug;
289(38):25996-26006.
PMID: 25078100
Mounting evidence suggests that human pancreatic ribonuclease (RNase 1) plays important roles in vivo, ranging from regulating blood clotting and inflammation to directly counteracting tumorigenic cells. Understanding these putative roles...
8.
Tonelli M, Eller C, Singarapu K, Lee W, Bahrami A, Westler W, et al.
Biomol NMR Assign
. 2014 Mar;
9(1):81-8.
PMID: 24619609
We report here backbone (1)H and (15)N assignments for ribonuclease A obtained by using ADAPT-NMR, a fully-automated approach for combined data collection, spectral analysis and resonance assignment. ADAPT-NMR was able...
9.
Sundlass N, Eller C, Cui Q, Raines R
Biochemistry
. 2013 Aug;
52(37):6304-12.
PMID: 23947917
Pancreatic-type ribonucleases show clinical promise as chemotherapeutic agents but are limited in efficacy by the inefficiency of their uptake by human cells. Cellular uptake can be increased by the addition...
10.
Lomax J, Eller C, Raines R
Methods Enzymol
. 2012 Jan;
502:273-90.
PMID: 22208989
Mammalian pancreatic-type ribonucleases (ptRNases) comprise an enzyme family that is remarkably well suited for therapeutic exploitation. ptRNases are robust and prodigious catalysts of RNA cleavage that can naturally access the...