Rodney Rothstein
Overview
Explore the profile of Rodney Rothstein including associated specialties, affiliations and a list of published articles.
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99
Citations
5432
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Recent Articles
1.
Mangione R, Pierce S, Zheng M, Martin R, Goncalves C, Kumar A, et al.
Nat Commun
. 2025 Mar;
16(1):2401.
PMID: 40064914
While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed that a...
2.
Repair of replication-dependent double-strand breaks differs between the leading and lagging strands
Kimble M, Sane A, Reid R, Johnson M, Rothstein R, Symington L
Mol Cell
. 2024 Dec;
85(1):61-77.e6.
PMID: 39631395
Single-strand breaks (SSBs) are one of the most commonly occurring endogenous lesions with the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA replication. To investigate how replication-dependent...
3.
Matulova P, Marini V, Burgess R, Sisakova A, Kwon Y, Rothstein R, et al.
J Biol Chem
. 2024 Oct;
300(10):107747.
PMID: 39383702
No abstract available.
4.
Kimble M, Sane A, Reid R, Johnson M, Rothstein R, Symington L
bioRxiv
. 2024 Jul;
PMID: 38948862
Single-strand breaks (SSBs) are one of the most common endogenous lesions and have the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA replication. To investigate the mechanism...
5.
Steinfeld J, Belan O, Kwon Y, Terakawa T, Al-Zain A, Smith M, et al.
Genes Dev
. 2024 May;
38(7-8):354.
PMID: 38772725
No abstract available.
6.
Giacomini G, Piquet S, Chevallier O, Dabin J, Bai S, Kim B, et al.
Nucleic Acids Res
. 2024 Jan;
52(5):2372-2388.
PMID: 38214234
Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with recurrent mutations in histone H3.3. These mutations promote oncogenesis by dysregulating gene expression through alterations of histone modifications. We...
7.
Greene E, Rothstein R
Curr Opin Genet Dev
. 2021 Nov;
71:iii-vii.
PMID: 34764004
No abstract available.
8.
Palancade B, Rothstein R
Cells
. 2021 Jul;
10(6).
PMID: 34201169
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity. Strikingly, different enzymatic activities classically involved in genome maintenance...
9.
Sustic T, van Wageningen S, Bosdriesz E, Reid R, Dittmar J, Lieftink C, et al.
Genome Med
. 2021 Feb;
13(1):24.
PMID: 33568196
No abstract available.
10.
Joseph F, Lee S, Bryant E, Rothstein R
Methods Mol Biol
. 2020 Aug;
2153:253-265.
PMID: 32840785
The precise organization of the genome inside the cell nucleus is vital to many cell functions including gene expression, cell division, and DNA repair. Here we describe a method to...