Lorraine S Symington
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Explore the profile of Lorraine S Symington including associated specialties, affiliations and a list of published articles.
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91
Citations
6956
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Recent Articles
1.
Repair of replication-dependent double-strand breaks differs between the leading and lagging strands
Kimble M, Sane A, Reid R, Johnson M, Rothstein R, Symington L
Mol Cell
. 2024 Dec;
85(1):61-77.e6.
PMID: 39631395
Single-strand breaks (SSBs) are one of the most commonly occurring endogenous lesions with the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA replication. To investigate how replication-dependent...
2.
Triplett M, Johnson M, Symington L
DNA Repair (Amst)
. 2024 Aug;
142:103753.
PMID: 39190984
DNA replication stress is one of the primary causes of genome instability. In response to replication stress, cells can employ replication restart mechanisms that rely on homologous recombination to resume...
3.
Kimble M, Sane A, Reid R, Johnson M, Rothstein R, Symington L
bioRxiv
. 2024 Jul;
PMID: 38948862
Single-strand breaks (SSBs) are one of the most common endogenous lesions and have the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA replication. To investigate the mechanism...
4.
Steinfeld J, Belan O, Kwon Y, Terakawa T, Al-Zain A, Smith M, et al.
Genes Dev
. 2024 May;
38(7-8):354.
PMID: 38772725
No abstract available.
5.
Galanti L, Peritore M, Gnugge R, Cannavo E, Heipke J, Palumbieri M, et al.
Nat Commun
. 2024 Apr;
15(1):2890.
PMID: 38570537
DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB repair pathway choice occurs at the level of DNA end resection and is controlled by the cell...
6.
Marie L, Kimble M, Symington L
Methods Cell Biol
. 2024 Feb;
182:35-48.
PMID: 38359986
Homologous recombination is a conserved process that cells use to repair damaged DNA. Many genetic assays have been developed in Saccharomyces cerevisiae to measure and characterize different types of recombination...
7.
Meir A, Raina V, Rivera C, Marie L, Symington L, Greene E
Nat Commun
. 2023 Dec;
14(1):8144.
PMID: 38065943
Srs2 is an Sf1a helicase that helps maintain genome stability in Saccharomyces cerevisiae through its ability to regulate homologous recombination. Srs2 downregulates HR by stripping Rad51 from single-stranded DNA, and...
8.
Al-Zain A, Nester M, Ahmed I, Symington L
Nat Commun
. 2023 Nov;
14(1):7020.
PMID: 37919272
Inverted duplications, also known as foldback inversions, are commonly observed in cancers and are the major class of chromosome rearrangement recovered from yeast cells lacking Mre11 nuclease activity. Foldback priming...
9.
Kimble M, Johnson M, Nester M, Symington L
Elife
. 2023 Jun;
12.
PMID: 37387287
Homologous recombination (HR), the high-fidelity mechanism for double-strand break (DSB) repair, relies on DNA end resection by nucleolytic degradation of the 5'-terminated ends. However, the role of long-range resection mediated...
10.
Gnugge R, Reginato G, Cejka P, Symington L
Mol Cell
. 2023 Mar;
83(8):1237-1250.e15.
PMID: 36917982
DNA double-strand breaks (DSBs) are cytotoxic genome lesions that must be accurately and efficiently repaired to ensure genome integrity. In yeast, the Mre11-Rad50-Xrs2 (MRX) complex nicks 5'-terminated DSB ends to...