Kara A Bernstein
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Explore the profile of Kara A Bernstein including associated specialties, affiliations and a list of published articles.
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59
Citations
2117
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Recent Articles
1.
Fagunloye A, De Magis A, Little J, Contreras I, Dorwart T, Bonilla B, et al.
EMBO J
. 2025 Jan;
44(5):1512-1539.
PMID: 39838174
Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis. Here we examine how yeast cells require...
2.
Thrasher J, Fagunloye A, Justiniano F, Bernstein K, Jensen R
bioRxiv
. 2024 Oct;
PMID: 39416194
Homologous recombination (HR) is an important mechanism for repairing DNA double-strand breaks (DSBs) and preserving genome integrity. Pathogenic mutations in the HR proteins BRCA2 and the RAD51 paralogs predispose individuals...
3.
Hengel S, Oppenheimer K, Smith C, Schaich M, Rein H, Martino J, et al.
Nat Commun
. 2024 Aug;
15(1):7197.
PMID: 39169038
Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a...
4.
Raices M, Balmir F, Silva N, Li W, Grundy M, Hoffman D, et al.
bioRxiv
. 2024 Mar;
PMID: 38463951
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes....
5.
Hengel S, Oppenheimer K, Smith C, Schaich M, Rein H, Martino J, et al.
bioRxiv
. 2024 Feb;
PMID: 38405734
Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a...
6.
Rein H, Bernstein K
DNA Repair (Amst)
. 2024 Feb;
135:103644.
PMID: 38330859
In the 20+ years since the discovery of RAD51C, scientists have been perplexed as to how missense variants in this tumor suppressor gene impacts its function and pathogenicity. With a...
7.
Rein H, Bernstein K
DNA Repair (Amst)
. 2023 Aug;
130:103563.
PMID: 37651978
For many individuals harboring a variant of uncertain functional significance (VUS) in a homologous recombination (HR) gene, their risk of developing breast and ovarian cancer is unknown. Integral to the...
8.
Wan L, Toland S, Robinson-McCarthy L, Lee N, Schaich M, Hengel S, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2308010120.
PMID: 37459531
Cellular eukaryotic replication initiation helicases are first loaded as head-to-head double hexamers on double-stranded (ds) DNA origins and then initiate S-phase DNA melting during licensed (once per cell cycle) replication....
9.
Rawal Y, Jia L, Meir A, Zhou S, Kaur H, Ruben E, et al.
Nature
. 2023 Jun;
619(7970):640-649.
PMID: 37344589
Homologous recombination (HR) fulfils a pivotal role in the repair of DNA double-strand breaks and collapsed replication forks. HR depends on the products of several paralogues of RAD51, including the...
10.
Luong T, Li Z, Priedigkeit N, Parker P, Bohm S, Rapchak K, et al.
PLoS Genet
. 2022 Sep;
18(9):e1010122.
PMID: 36126066
Human RECQL4 is a member of the RecQ family of DNA helicases and functions during DNA replication and repair. RECQL4 mutations are associated with developmental defects and cancer. Although RECQL4...