Robin J Thomson
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Explore the profile of Robin J Thomson including associated specialties, affiliations and a list of published articles.
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27
Citations
178
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Recent Articles
1.
Earley D, Bailly B, Maggioni A, Kundur A, Thomson R, Chang C, et al.
ACS Infect Dis
. 2019 Jul;
5(10):1708-1717.
PMID: 31307190
Enterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS)...
2.
Chibanga V, Dirr L, Guillon P, El-Deeb I, Bailly B, Thomson R, et al.
Antiviral Res
. 2019 Apr;
167:89-97.
PMID: 30951732
Human parainfluenza viruses cause acute respiratory tract infections and disease predominantly in young children and immunocompromised individuals. Currently, there are no vaccines to prevent hPIV infections, nor licensed anti-hPIV drugs....
3.
Pascolutti M, Dirr L, Guillon P, Van Den Bergh A, Ve T, Thomson R, et al.
ACS Chem Biol
. 2018 Apr;
13(6):1544-1550.
PMID: 29693380
A novel approach to human parainfluenza virus 3 (hPIV-3) inhibitor design has been evaluated by targeting an unexplored pocket within the active site region of the hemagglutinin-neuraminidase (HN) of the...
4.
Hadhazi A, Li L, Bailly B, Maggioni A, Martin G, Dirr L, et al.
ChemMedChem
. 2018 Feb;
13(8):785-789.
PMID: 29453852
Influenza virus infection continues to cause significant, often severe, respiratory illness worldwide. A validated target for the development of anti-influenza agents is the virus surface protein sialidase. In the current...
5.
Hadhazi A, Pascolutti M, Bailly B, Dyason J, Borbas A, Thomson R, et al.
Org Biomol Chem
. 2017 May;
15(25):5249-5253.
PMID: 28540971
A new direction for influenza virus sialidase inhibitor development was identified using a sulfonate congener of 2-deoxy-2-β-H N-acetylneuraminic acid. Sialosyl sulfonates can be synthesised efficiently in four steps from N-acetylneuraminic...
6.
Madge P, Maggioni A, Pascolutti M, Amin M, Waespy M, Bellette B, et al.
Sci Rep
. 2016 Nov;
6:36012.
PMID: 27808110
Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin's lymphoma (NHL)....
7.
Bohlmann L, Tredwell G, Yu X, Chang C, Haselhorst T, Winger M, et al.
Nat Chem Biol
. 2015 Nov;
11(12):955-7.
PMID: 26565989
We report the structural and functional characterization of a novel heparanase (BpHep) from the invasive pathogenic bacterium Burkholderia pseudomallei (Bp), showing ∼24% sequence identity with human heparanase (hHep). Site-directed mutagenesis...
8.
Wu Y, Vavricka C, Wu Y, Li Q, Rudrawar S, Thomson R, et al.
Protein Cell
. 2015 Sep;
6(10):771-3.
PMID: 26334400
No abstract available.
9.
Pascolutti M, Madge P, Thomson R, von Itzstein M
J Org Chem
. 2015 Jun;
80(15):7746-51.
PMID: 26118975
Direct access to 3-O-functionalized 2-α-N-acetylneuraminides and their corresponding 2,3-dehydro-2-deoxy-N-acetylneuraminic acid derivatives is described. Initially, a stereoselective ring-opening of the key intermediate N-acetylneuraminic acid (Neu5Ac) 2,3-β-epoxide with an alcohol provided the...
10.
Rudrawar S, Dyason J, Maggioni A, Thomson R, von Itzstein M
Bioorg Med Chem
. 2013 Jun;
21(16):4820-30.
PMID: 23800724
Novel 3,4-disubstituted-Neu5Ac2en derivatives have been synthesised to probe the open 150-loop conformation of influenza virus sialidases. Both equatorially and axially (epi) substituted C4 amino and guanidino 3-(p-tolyl)allyl-Neu5Ac2en derivatives were prepared,...