Robert Damoiseaux
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Explore the profile of Robert Damoiseaux including associated specialties, affiliations and a list of published articles.
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146
Citations
4450
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Recent Articles
1.
Wang J, Toh B, An J, Komuro Y, Godoy M, Putman J, et al.
bioRxiv
. 2025 Mar;
PMID: 40060510
Significance Statement: Axon degeneration is a pivotal event following ischemic stroke, however the mechanism of white matter loss in stroke is unknown. We demonstrate that the pro-degenerative molecule Sarm1 is...
2.
Castellon J, Yuen C, Han B, Andrews K, Ofori S, Julio A, et al.
RSC Chem Biol
. 2025 Feb;
PMID: 40013156
Caspases are a family of highly homologous cysteine proteases that play critical roles in inflammation and apoptosis. Small molecule inhibitors are useful tools for studying caspase biology, complementary to genetic...
3.
Sen C, Rickabaugh T, Jeyachandran A, Yuen C, Ghannam M, Durra A, et al.
Respir Res
. 2025 Jan;
26(1):18.
PMID: 39819574
Background: Many respiratory viruses attack the airway epithelium and cause a wide spectrum of diseases for which we have limited therapies. To date, a few primary human stem cell-based models...
4.
Storey C, Cheng M, Altai M, Park J, Tran J, Lueong S, et al.
bioRxiv
. 2024 Dec;
PMID: 39651139
Transforming growth factor-beta (TGFβ) has dual roles in cancer, initially suppressing tumors but later promoting metastasis and immune evasion. Efforts to inhibit TGFβ have been largely unsuccessful due to significant...
5.
Nichols Doyle R, Yang V, Kayode Y, Damoiseaux R, Taylor H, Fregoso O
Viruses
. 2024 Nov;
16(11).
PMID: 39599897
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the "kick and kill" (also called "shock and kill") approach, in which virus expression is...
6.
Geroyska S, Mejia I, Chan A, Navarrete M, Pandey V, Kharpatin S, et al.
Cancer Res Commun
. 2024 Jul;
4(7):1815-1833.
PMID: 38949950
Significance: KRAS-mutant lung carcinomas with LKB1 and/or KEAP1 co-mutations have intrinsic therapeutic resistance. We show that these tumors are sensitive to NMT inhibitors, which slow tumor growth in vivo and...
7.
Hong A, Moriceau G, Sun L, Lomeli S, Piva M, Damoiseaux R, et al.
Cancer Discov
. 2024 Jul;
14(7):1356.
PMID: 38946327
No abstract available.
8.
Castellon J, Ofori S, Burton N, Julio A, Turmon A, Armenta E, et al.
J Am Chem Soc
. 2024 May;
146(22):14972-14988.
PMID: 38787738
Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation. Complementary to genetic approaches, small-molecule probes have emerged...
9.
Wang Y, Cortes E, Huang R, Wan J, Zhao J, Hinz B, et al.
SLAS Discov
. 2023 Dec;
29(3):100138.
PMID: 38158044
The pivotal role of myofibroblast contractility in the pathophysiology of fibrosis is widely recognized, yet HTS approaches are not available to quantify this critically important function in drug discovery. We...
10.
Jeyachandran A, Irudayam J, Dubey S, Chakravarty N, Konda B, Shah A, et al.
bioRxiv
. 2023 Aug;
PMID: 37577539
Background: Hantaviruses - dichotomized into New World (i.e. Andes virus, ANDV; Sin Nombre virus, SNV) and Old-World viruses (i.e. Hantaan virus, HTNV) - are zoonotic viruses transmitted from rodents to...