Kenneth A Bradley
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Explore the profile of Kenneth A Bradley including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
1370
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Recent Articles
1.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jul;
631(8022):E17.
PMID: 38992182
No abstract available.
2.
Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis
Lieu D, Crowder M, Kryza J, Tamilselvam B, Kaminski P, Kim I, et al.
bioRxiv
. 2024 Jun;
PMID: 38826216
Macroautophagy is thought to have a critical role in shaping and refining cellular proteostasis in eukaryotic cells recovering from DNA damage. Here, we report a mechanism by which autophagy is...
3.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jan;
625(7995):566-571.
PMID: 38172634
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options. No new antibiotic chemical class with activity against A. baumannii has reached patients in over...
4.
Martchenko Shilman M, Bartolo G, Alameh S, Peterson J, Lawrence W, Peel J, et al.
ACS Infect Dis
. 2021 Jul;
7(8):2176-2191.
PMID: 34218660
Anthrax is caused by and can result in nearly 100% mortality due in part to anthrax toxin. Antimalarial amodiaquine (AQ) acts as a host-oriented inhibitor of anthrax toxin endocytosis. Here,...
5.
Hartmann S, Nusbaum D, Kim K, Alameh S, Ho C, Cruz R, et al.
ACS Infect Dis
. 2018 Oct;
4(12):1746-1754.
PMID: 30354048
Inflammasomes activate caspase-1 in response to molecular signals from pathogens and other dangerous stimuli as a part of the innate immune response. A previous study discovered a small-molecule, 4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide,...
6.
Hartmann S, Lopez Cruz R, Alameh S, Ho C, Rabideau A, Pentelute B, et al.
ACS Infect Dis
. 2018 May;
4(8):1235-1245.
PMID: 29749721
Exploiting the host endocytic trafficking pathway is a common mechanism by which bacterial exotoxins gain entry to exert virulent effects upon the host cells. A previous study identified a small-molecule,...
7.
Dixon S, Huynh M, Tamilselvam B, Spiegelman L, Son S, Eshraghi A, et al.
PLoS One
. 2015 Dec;
10(11):e0143977.
PMID: 26618479
Cytolethal distending toxins (CDTs) are heterotrimeric protein exotoxins produced by a diverse array of Gram-negative pathogens. The enzymatic subunit, CdtB, possesses DNase and phosphatidylinositol 3-4-5 trisphosphate phosphatase activities that induce...
8.
McComb R, Ho C, Bradley K, Grill L, Martchenko M
Vaccine
. 2015 Oct;
33(48):6745-51.
PMID: 26514421
The current anthrax vaccine requires improvements for rapidly invoking longer-lasting neutralizing antibody responses with fewer doses from a well-defined formulation. Designing antigens that target neutralizing antibody epitopes of anthrax protective...
9.
Zilbermintz L, Leonardi W, Jeong S, Sjodt M, McComb R, Ho C, et al.
Sci Rep
. 2015 Aug;
5:13476.
PMID: 26310922
A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the targeting of host proteins and pathways essential for the detrimental effects...
10.
Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1
Ting P, Damoiseaux R, Titz B, Bradley K, Graeber T, Fernandez-Vega V, et al.
PLoS One
. 2015 Mar;
10(3):e0121833.
PMID: 25811598
Constitutively active BCR-ABL kinase fusions are causative mutations in the pathogenesis of hematopoietic neoplasias including chronic myelogenous leukemia (CML). Although these fusions have been successfully targeted with kinase inhibitors, drug-resistance...