N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Jul 1

PMID 38949950

Authors

Sofia Geroyska

Isabel Mejia

Alfred A Chan

Marian Navarrete

Vijaya Pandey

Samuel Kharpatin

Juliana Noguti

Feng Wang

Daniel Srole

Tsui-Fen Chou

James Wohlschlegel

Elizabeta Nemeth

Robert Damoiseaux

David B Shackelford

Delphine J Lee

Begona Diaz

Affiliations

Soon will be listed here.

Abstract

Significance: KRAS-mutant lung carcinomas with LKB1 and/or KEAP1 co-mutations have intrinsic therapeutic resistance. We show that these tumors are sensitive to NMT inhibitors, which slow tumor growth in vivo and sensitize cells to platinum-based chemotherapy in vitro. Inhibition of myristoylation causes death by parthanatos and thus has the potential to kill apoptosis and ferroptosis-resistant cancer cells. Our findings warrant investigation of NMT as a therapeutic target in highly aggressive lung carcinomas.

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