Robert Damoiseaux
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Explore the profile of Robert Damoiseaux including associated specialties, affiliations and a list of published articles.
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146
Citations
4450
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Recent Articles
11.
Lee M, Ratanachan D, Wang Z, Hack J, Adbulrahman L, Shamlin N, et al.
J Immunol
. 2023 Jul;
211(4):693-705.
PMID: 37395687
Ionizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing...
12.
Nichols Doyle R, Yang V, Kayode Y, Damoiseaux R, Taylor H, Fregoso O
bioRxiv
. 2023 Jun;
PMID: 37293110
The latent viral reservoir represents one of the major barriers of curing HIV-1. Focus on the "kick and kill" approach, in which virus expression is reactivated then cells producing virus...
13.
Sinha S, Mellody M, Carpio M, Damoiseaux R, Nicholas S
Biomedicines
. 2023 May;
11(5).
PMID: 37239027
Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the...
14.
Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt E, et al.
Clin Cancer Res
. 2023 May;
29(16):3130-3141.
PMID: 37195712
Purpose: Stimulator of interferon genes (STING) agonists are currently in development for treatment of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Response rates to STING agonists alone have been promising...
15.
Tayeb-Fligelman E, Bowler J, Tai C, Sawaya M, Jiang Y, Garcia Jr G, et al.
Nat Commun
. 2023 May;
14(1):2379.
PMID: 37185252
The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs...
16.
Ghezzi C, Chen B, Damoiseaux R, Clark P
Sci Rep
. 2023 Jan;
13(1):1442.
PMID: 36697489
Squamous cell lung cancer maintains its growth through elevated glucose consumption, but selective glucose consumption inhibitors are lacking. Here, we discovered using a high-throughput screen new compounds that block glucose...
17.
Storey C, Altai M, Bicak M, Veach D, Luckerath K, Adrian G, et al.
Mol Cancer Res
. 2023 Jan;
21(4):307-315.
PMID: 36608299
Implications: hK2 expression in prostate cancer tissue is a proxy of EBRT-induced AR activity that can noninvasively be detected using [89Zr]11B6-PET; further clinical evaluation of hK2-PET for monitoring response and...
18.
Ghezzi C, Perez S, Ryan K, Wong A, Chen B, Damoiseaux R, et al.
Mol Imaging Biol
. 2022 Oct;
25(3):541-553.
PMID: 36284040
Purpose: Small molecule inhibitors that target oncogenic driver kinases are an important class of therapies for non-small cell lung cancer (NSCLC) and other malignancies. However, these therapies are not without...
19.
Scoles D, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa K, et al.
J Biol Chem
. 2022 Jul;
298(8):102228.
PMID: 35787375
CAG repeat expansions in the ATXN2 (ataxin-2) gene can cause the autosomal dominant disorder spinocerebellar ataxia type 2 (SCA2) as well as increase the risk of ALS. Abnormal molecular, motor,...
20.
Liang J, Sohrabi A, Epperson M, Rad L, Tamura K, Sathialingam M, et al.
J Vis Exp
. 2022 Jul;
(184).
PMID: 35781280
Cell-matrix interactions mediate complex physiological processes through biochemical, mechanical, and geometrical cues, influencing pathological changes and therapeutic responses. Accounting for matrix effects earlier in the drug development pipeline is expected...