Richard Flavell
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Explore the profile of Richard Flavell including associated specialties, affiliations and a list of published articles.
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74
Citations
6013
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Recent Articles
21.
Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, et al.
J Immunol
. 2015 Jan;
194(4):1894-904.
PMID: 25595781
Idiopathic pulmonary fibrosis is a devastating lung disease characterized by inflammation and the development of excessive extracellular matrix deposition. Currently, there are only limited therapeutic intervenes to offer patients diagnosed...
22.
Amezcua C, Gagliani N, Flavell R
J Exp Med
. 2014 Nov;
211(12):2328-9.
PMID: 25403806
No abstract available.
23.
Wegiel B, Larsen R, Gallo D, Chin B, Harris C, Mannam P, et al.
J Clin Invest
. 2014 Oct;
124(11):4926-40.
PMID: 25295542
Microbial clearance by eukaryotes relies on complex and coordinated processes that remain poorly understood. The gasotransmitter carbon monoxide (CO) is generated by the stress-responsive enzyme heme oxygenase-1 (HO-1, encoded by...
24.
Chen X, Shen Y, Liang Q, Flavell R, Hong Z, Yin Z, et al.
Int Immunopharmacol
. 2014 Feb;
19(2):399-404.
PMID: 24508059
Bavachinin, which can be isolated from the Chinese herb Fructus Psoraleae, has the potential as a potent anti-asthma drug. However, the extremely low water solubility of Bavachinin limits its application....
25.
Hacisuleyman E, Goff L, Trapnell C, Williams A, Henao-Mejia J, Sun L, et al.
Nat Struct Mol Biol
. 2014 Jan;
21(2):198-206.
PMID: 24463464
RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important structural component of the nuclear matrix. However, the molecular identities, functional roles and localization dynamics of...
26.
Chen X, Wen T, Wei J, Wu Z, Wang P, Hong Z, et al.
Cell Mol Immunol
. 2013 Sep;
10(6):497-505.
PMID: 24013845
Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation....
27.
Chaiyachati B, Jani A, Wan Y, Huang H, Flavell R, Chi T
EMBO J
. 2013 Jan;
32(3):395-408.
PMID: 23321680
Treg activation in response to environmental cues is necessary for regulatory T cells (Tregs) to suppress inflammation, but little is known about the transcription mechanisms controlling Treg activation. We report...
28.
Chaiyachati B, Kaundal R, Zhao J, Wu J, Flavell R, Chi T
BMC Biol
. 2012 Dec;
10:96.
PMID: 23198860
Background: Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is...
29.
Dela Cruz C, Liu W, He C, Jacoby A, Gornitzky A, Ma B, et al.
Cell Host Microbe
. 2012 Jul;
12(1):34-46.
PMID: 22817986
Host antibacterial responses include mechanisms that kill bacteria, but also those that protect or tolerize the host to potentially damaging antibacterial effects. We determined that Chitinase 3-like-1 (Chi3l1), a conserved...
30.
Macal M, Lewis G, Kunz S, Flavell R, Harker J, Zuniga E
Cell Host Microbe
. 2012 Jun;
11(6):617-30.
PMID: 22704622
The antiviral response is largely mediated by dendritic cells (DCs), including conventional (c) DCs that function as antigen-presenting cells, and plasmacytoid (p) DCs that produce type I interferons, making them...