Treatment of Allergic Inflammation and Hyperresponsiveness by a Simple Compound, Bavachinin, Isolated from Chinese Herbs

Overview

Journal Cell Mol Immunol

Date 2013 Sep 10

PMID 24013845

Citations 3

Authors

Xi Chen

Ti Wen

Jun Wei

Zhenzhou Wu

Puyue Wang

Zhangyong Hong

Liqing Zhao

Bin Wang

Richard Flavell

Shumei Gao

Min Wang

Zhinan Yin

Affiliations

Soon will be listed here.

Abstract

Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.

Citing Articles

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