Ricardo J Nunes
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Explore the profile of Ricardo J Nunes including associated specialties, affiliations and a list of published articles.
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40
Citations
226
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Recent Articles
1.
Jacques A, Stefanes N, Walter L, Syracuse S, Bigolin A, Chiaradia-Delatorre L, et al.
Fundam Clin Pharmacol
. 2025 Jan;
39(1):e13047.
PMID: 39749431
Background: Chalcones have been described in the literature as promising antineoplastic compounds. Objectives: Therefore, the objective of this study was to analyze the cytotoxic effect of 23 synthetic chalcones on...
2.
Machado V, Cenci A, Teixeira K, Sens L, Tizziani T, Nunes R, et al.
RSC Med Chem
. 2022 Dec;
13(12):1644-1656.
PMID: 36561075
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized as the main dementia in the elderly. Eighteen pyrazolines were synthesized and evaluated for their inhibitory effects against acetylcholinesterase (AChE)...
3.
S de Oliveira A, Valli M, Ferreira L, Souza J, Krogh R, Meier L, et al.
Future Med Chem
. 2022 May;
14(11):795-808.
PMID: 35543430
Chagas disease is a neglected tropical disease that affects millions of people worldwide and for which no effective treatment is available. 17 chalcones were synthesized, for which the inhibition of...
4.
Tramontini Gomes de Sousa F, Biering S, Patel T, Blanc S, Camelini C, Venzke D, et al.
Antiviral Res
. 2022 May;
203:105330.
PMID: 35533778
Despite substantial morbidity and mortality, no therapeutic agents exist for treatment of dengue or Zika, and the currently available dengue vaccine is only recommended for dengue virus (DENV)-immune individuals. Thus,...
5.
S de Oliveira A, Llanes L, Nunes R, Nucci-Martins C, de Souza A, Palomino-Salcedo D, et al.
Front Pharmacol
. 2021 Dec;
12:788850.
PMID: 34887769
The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol-a druglike natural product-are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine () demonstrated...
6.
de Souza A, Mori M, Sens L, Rocha R, Tizziani T, de Souza L, et al.
Bioorg Med Chem Lett
. 2020 Jul;
30(16):127350.
PMID: 32631548
Identification of allosteric inhibitors of PTPs has attracted great interest as a new strategy to overcome the challenge of discover potent and selective molecules for therapeutic intervention. YopH is a...
7.
Maioral M, Stefanes N, Neuenfeldt P, Chiaradia-Delatorre L, Nunes R, Santos-Silva M
Future Med Chem
. 2020 Mar;
12(8):673-688.
PMID: 32191531
Investigate the apoptotic mechanisms of two new aldehyde biphenyl chalcones on leukemia cells. From a series of 71 new chalcones, we selected the two most cytotoxic. and were cytotoxic not...
8.
S de Oliveira A, de Souza L, Nunes R, Johann S, Palomino-Salcedo D, Ferreira L, et al.
Curr Top Med Chem
. 2019 Nov;
20(3):173-181.
PMID: 31775599
Background: Bacterial resistance to antibiotics is a growing problem in all countries and has been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is highly...
9.
Rengifo A, Stefanes N, Toigo J, Mendes C, Santos-Silva M, Nunes R, et al.
Mater Sci Eng C Mater Biol Appl
. 2019 Sep;
105:110051.
PMID: 31546341
We describe herein a chitosan nanocarrier for drug delivery applications obtained through the self-assembly of carboxymethyl-hexanoyl chitosan and dodecyl sulfate (CHC-SDS). Nanocapsules with spherical morphology were obtained in phosphate buffer...
10.
Perondi D, Jacques A, Stefanes N, Maioral M, Sens L, Pacheco L, et al.
Anticancer Drugs
. 2019 Apr;
30(8):828-837.
PMID: 30932944
Acute leukemias are a heterogeneous group of aggressive malignant neoplasms associated with severe morbidities due to the nonselectivity of current chemotherapeutic drugs to nonmalignant cells. The investigation of novel natural...