Paulo C Leal
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Explore the profile of Paulo C Leal including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
220
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Recent Articles
1.
de Vasconcellos J, Laranjeira A, Leal P, Bhasin M, Zenatti P, Nunes R, et al.
PLoS One
. 2015 Aug;
10(8):e0134783.
PMID: 26302043
Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially described as a...
2.
Salum L, Mascarello A, Canevarolo R, Altei W, Laranjeira A, Neuenfeldt P, et al.
Eur J Med Chem
. 2015 May;
96:504-18.
PMID: 25951294
Tubulin-interacting agents, like vinca alkaloid and taxanes, play a fundamental role in cancer chemotherapy, making cellular microtubules (MT), one of the few validated anticancer targets. Cancer resistance to classical MT...
3.
Romanini J, Mielcke T, Leal P, Figueiredo C, Calixto J, Morrone F, et al.
Invest New Drugs
. 2011 Jun;
30(4):1371-8.
PMID: 21670971
This study evaluated the relevance of CXCR2 chemokine receptors in oral squamous cell carcinoma, by means of in vitro and in vivo approaches. The in vitro incubation of the selective...
4.
Santos Jr A, Leal P, Edelweiss M, Lopes T, Calixto J, Morrone F, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2010 Sep;
382(5-6):399-407.
PMID: 20809237
Hemorrhagic cystitis (HC) is a common side effect observed in patients under chemotherapy with cyclophosphamide (CYP). The urotoxic side effects of CYP are attributed to the metabolic compound acrolein, and...
5.
Passos G, Figueiredo C, Prediger R, Silva K, Siqueira J, Duarte F, et al.
Brain Behav Immun
. 2009 Dec;
24(3):493-501.
PMID: 20025958
Alzheimer disease (AD) is the most common form of dementia in the elderly, and the neuro-pathological hallmarks of AD include neurofibrillary tangles (NFT), and deposition of beta-amyloid (Abeta) in extracellular...
6.
Viana A, Maciel I, Motta E, Leal P, Pianowski L, Campos M, et al.
Evid Based Complement Alternat Med
. 2009 Oct;
2011:120820.
PMID: 19815648
Trichilia catigua is a native plant of Brazil; its barks are used by some local pharmaceutical companies to prepare tonic drinks, such as Catuama. The present study was addressed to...
7.
Locatelli C, Leal P, Yunes R, Nunes R, Creczynski-Pasa T
Chem Biol Interact
. 2009 Jul;
181(2):175-84.
PMID: 19577552
Malignant melanoma is a lethal disease, and the incidence and mortality associated with it are increasing worldwide. It has a significant tendency to develop both metastasis and resistance to chemotherapy....
8.
Manjavachi M, Quintao N, Campos M, Deschamps I, Yunes R, Nunes R, et al.
Eur J Pain
. 2009 Mar;
14(1):23-31.
PMID: 19264522
This study evaluated the antinociceptive effects of the selective and non-peptide CXCR2 antagonist SB225002 in mouse models of pain. As assessed in different tests of spontaneous nociception, intraperitoneal (i.p.) administration...
9.
Campos M, Leal P, Yunes R, Calixto J
Trends Pharmacol Sci
. 2006 Oct;
27(12):646-51.
PMID: 17056130
Kinin B1 and B2 receptors are central to the aetiology of pain and inflammation. Constitutive B2 receptors are commonly associated with the acute phase of inflammation and nociception, whereas the...
10.
Rosso R, Vieira T, Leal P, Nunes R, Yunes R, Creczynski-Pasa T
Bioorg Med Chem
. 2006 Jun;
14(18):6409-13.
PMID: 16759870
The gallic acid and several n-alkyl gallates, with the same number of hydroxyl substituents, varying only in the side carbonic chain length, with respective lipophilicity defined through the C log...