Ricardo J Nunes
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Explore the profile of Ricardo J Nunes including associated specialties, affiliations and a list of published articles.
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40
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226
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Recent Articles
11.
Muradas T, Abbadi B, Villela A, Macchi F, Bergo P, de Freitas T, et al.
PLoS One
. 2018 Aug;
13(8):e0202568.
PMID: 30114296
New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules,...
12.
Mendes C, Postal B, Oliveira G, Castro A, Frederico M, Moraes A, et al.
J Cell Physiol
. 2018 Jul;
234(1):509-520.
PMID: 29968920
New compounds with promising antidiabetic activity were synthesized. For the first time, a portion of the glibenclamide molecule was bound to a part of the core structure of thiazolidinedione to...
13.
Kelmann R, Colombo M, Nunes R, SimOes C, Koester L
AAPS PharmSciTech
. 2018 Jun;
19(6):2672-2678.
PMID: 29943283
The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n-alkyl ester, through the skin. PG is an antioxidant...
14.
Mielcke T, Muradas T, Filippi-Chiela E, Amaral M, Kist L, Bogo M, et al.
Sci Rep
. 2017 Nov;
7(1):15850.
PMID: 29158524
The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9,...
15.
Frederico M, Castro A, Pinto V, Ramos C, Monteiro F, Mascarello A, et al.
J Cell Biochem
. 2017 Nov;
119(6):4408-4419.
PMID: 29130561
The aim of the present study was to investigate the mechanism of action of a sulfonamide derivative on glucose uptake in adipose tissue, as well as to characterize the effects...
16.
Cordova C, Locatelli C, Winter E, Silva A, Zanetti-Ramos B, Jasper R, et al.
Anticancer Drugs
. 2017 Jul;
28(9):977-988.
PMID: 28746057
Metastasis is the main cause of cancer-related death and requires the development of effective treatments with reduced toxicity and effective anticancer activity. Gallic acid derivatives have shown significant biological properties...
17.
Kelmann R, Colombo M, de Araujo Lopes S, Nunes R, Pistore M, Dall Agnol D, et al.
J Pharm Sci
. 2016 Jun;
105(7):2194-203.
PMID: 27290627
Previous studies have demonstrated the antiherpes activity of pentyl gallate (PG), suggesting that it could be a promising candidate for the topical treatment of human herpes labialis. PG low aqueous...
18.
de Vasconcellos J, Laranjeira A, Leal P, Bhasin M, Zenatti P, Nunes R, et al.
PLoS One
. 2015 Aug;
10(8):e0134783.
PMID: 26302043
Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially described as a...
19.
Figueiredo C, Ferreira N, Passos G, da Costa R, Neves F, Machado C, et al.
An Acad Bras Cienc
. 2015 Aug;
87(2 Suppl):1421-34.
PMID: 26247149
An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic...
20.
Salum L, Mascarello A, Canevarolo R, Altei W, Laranjeira A, Neuenfeldt P, et al.
Eur J Med Chem
. 2015 May;
96:504-18.
PMID: 25951294
Tubulin-interacting agents, like vinca alkaloid and taxanes, play a fundamental role in cancer chemotherapy, making cellular microtubules (MT), one of the few validated anticancer targets. Cancer resistance to classical MT...