Alessandra Mascarello
Overview
Explore the profile of Alessandra Mascarello including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
48
Citations
377
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
de Souza Gama F, Dutra L, Hawgood M, Dos Reis C, Serafim R, Ferreira Jr M, et al.
J Med Chem
. 2024 May;
67(11):8609-8629.
PMID: 38780468
Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases...
2.
Segretti N, Takarada J, Ferreira Jr M, Da Silva Santiago A, Teodoro B, Damiao M, et al.
Bioorg Med Chem Lett
. 2022 May;
68:128764.
PMID: 35504513
The discovery of potent and selective inhibitors for understudied kinases can provide relevant pharmacological tools to illuminate their biological functions. DYRK1A and DYRK1B are protein kinases linked to chronic human...
3.
Ferreira Jr M, Azevedo H, Mascarello A, Segretti N, Russo E, Russo V, et al.
J Med Chem
. 2021 Feb;
64(4):1904-1929.
PMID: 33626870
The modulation of melatonin signaling in peripheral tissues holds promise for treating metabolic diseases like obesity, diabetes, and nonalcoholic steatohepatitis. Here, several benzimidazole derivatives have been identified as novel agonists...
4.
Mascarello A, Azevedo H, Junior M, Ishikawa E, Ruch Werneck Guimaraes C
Eur J Pharm Sci
. 2021 Jan;
159:105731.
PMID: 33493668
The multifactorial etiology of hypertension has promoted the research of blood pressure-lowering agents with multitarget actions to achieve better clinical outcomes. We describe here the discovery of novel dual-acting antihypertensive...
5.
Azevedo H, Ferreira M, Mascarello A, Osten P, Ruch Werneck Guimaraes C
Neurobiol Stress
. 2020 Jun;
13:100226.
PMID: 32478146
Post-traumatic stress disorder (PTSD) is a mental health condition that is triggered by a stressful event, with symptoms including exaggerated startle response, intrusive traumatic memories and nightmares. The single prolonged...
6.
Azevedo H, Ferreira M, Mascarello A, Osten P, Ruch Werneck Guimaraes C
Neuropharmacology
. 2019 Dec;
164:107912.
PMID: 31843397
Post-traumatic stress disorder (PTSD) is a severe chronic mental illness that develops in individuals exposed to life-threatening trauma and is characterized by hyperarousal, flashbacks and nightmares. The serotonergic (5-HT) and...
7.
Serafim R, de Souza Gama F, Dutra L, Dos Reis C, Vasconcelos S, Da Silva Santiago A, et al.
ACS Med Chem Lett
. 2019 Sep;
10(9):1266-1271.
PMID: 31531195
Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders. Nevertheless, the cellular functions of these proteins are not...
8.
Azevedo H, Ferreira M, Watanabe Costa R, Russo V, Russo E, Mascarello A, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2019 Jul;
95:109707.
PMID: 31330215
Anxiety disorders are serious and common mental diseases, yet there is still a need for the development of more effective anxiolytics with better safety profiles than benzodiazepines and serotonin reuptake...
9.
Sulis P, Dambros B, Mascarello A, Dos Santos A, Yunes R, Nunes R, et al.
J Cell Physiol
. 2018 Nov;
234(7):10138-10147.
PMID: 30417369
Aim: To investigate the mechanism of action of sulfonyl(thio)urea derivative (SD) on glycemia and on insulin secretion in pancreatic islets. Methods: Wistar rats were divided into hyperglycemic control group, rats...
10.
Sens L, de Souza A, Pacheco L, Menegatti A, Mori M, Mascarello A, et al.
Bioorg Med Chem
. 2018 Nov;
26(21):5742-5750.
PMID: 30389409
Mycobacterium tuberculosis secretes two protein tyrosine phosphatases as virulence factors, PtpA and PtpB. Inhibition studies of these enzymes have shown significant attenuation of the M. tuberculosis growth in vivo. As...