Rene L Jacobs
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Explore the profile of Rene L Jacobs including associated specialties, affiliations and a list of published articles.
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93
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2702
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Recent Articles
11.
Ayer A, Fazakerley D, Suarna C, Maghzal G, Sheipouri D, Lee K, et al.
Redox Biol
. 2021 Sep;
46:102127.
PMID: 34521065
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and...
12.
Lian J, van der Veen J, Watts R, Jacobs R, Lehner R
J Lipid Res
. 2021 Jun;
62:100093.
PMID: 34153284
The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and...
13.
Aldana-Hernandez P, Azarcoya-Barrera J, van der Veen J, Leonard K, Zhao Y, Nelson R, et al.
J Nutr Biochem
. 2021 Mar;
92:108617.
PMID: 33705949
Choline is an essential nutrient required for various biological processes. Eggs, dairy, and meat are rich in phosphatidylcholine (PC), whereas cereal and legumes are rich in free choline. Excess dietary...
14.
Azarcoya-Barrera J, Field C, Goruk S, Makarowski A, Curtis J, Pouliot Y, et al.
Eur J Nutr
. 2021 Jan;
60(5):2807-2818.
PMID: 33416979
Purpose: To determine the effect of feeding buttermilk-derived choline metabolites on the immune system development in Sprague-Dawley rat pups. Methods: Sprague-Dawley dams were randomized to one of the three diets...
15.
Wilson R, Zhang R, Chen Y, Peters K, Sawyez C, Sutherland B, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33271781
Prolonged, isocaloric, time-restricted feeding (TRF) protocols can promote weight loss, improve metabolic dysregulation, and mitigate non-alcoholic fatty liver disease (NAFLD). In addition, 3-day, severe caloric restriction can improve liver metabolism...
16.
Kennelly J, Carlin S, Ju T, van der Veen J, Nelson R, Buteau J, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Nov;
11(4):999-1021.
PMID: 33238221
Background & Aims: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved...
17.
Wilson R, Chen Y, Sutherland B, Sawyez C, Zhang R, Woolnough T, et al.
Pharmacol Res
. 2020 Sep;
161:105208.
PMID: 32977024
Inhibition of eukaryotic elongation factor 1A1 (EEF1A1) with the marine compound didemnin B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty liver disease (NAFLD) in...
18.
Ju T, Kennelly J, Jacobs R, Willing B
Br J Nutr
. 2020 Aug;
125(1):50-61.
PMID: 32792032
Dietary choline, which is converted to phosphatidylcholine (PC) in intestinal enterocytes, may benefit inflammatory bowel disease patients who typically have reduced intestinal choline and PC. The present study investigated the...
19.
Azarcoya-Barrera J, Goruk S, Lewis E, Pouliot Y, Curtis J, Steele R, et al.
J Nutr
. 2020 Apr;
150(7):1958-1965.
PMID: 32271922
Background: Buttermilk contains a mixture of choline forms; it is high in phosphatidylcholine (PC) and sphingomyelin (SM), which could have an impact on immune system development and function. Objectives: We...
20.
Aldana-Hernandez P, Leonard K, Zhao Y, Curtis J, Field C, Jacobs R
J Nutr
. 2019 Sep;
150(2):249-255.
PMID: 31529091
Background: Choline, an essential nutrient, is required for cell membranes, lipoprotein secretion, and methyl-group metabolism. Recently, it has been proposed that excess dietary choline consumption is metabolized to trimethylamine (TMA)...