Jelske N van der Veen
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Explore the profile of Jelske N van der Veen including associated specialties, affiliations and a list of published articles.
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33
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1211
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Recent Articles
1.
Trzaskalski N, Vulesevic B, Nguyen M, Jeraj N, Fadzeyeva E, Morrow N, et al.
JCI Insight
. 2022 Dec;
8(2).
PMID: 36472923
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4...
2.
Ayer A, Fazakerley D, Suarna C, Maghzal G, Sheipouri D, Lee K, et al.
Redox Biol
. 2021 Sep;
46:102127.
PMID: 34521065
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and...
3.
Lian J, van der Veen J, Watts R, Jacobs R, Lehner R
J Lipid Res
. 2021 Jun;
62:100093.
PMID: 34153284
The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and...
4.
Aldana-Hernandez P, Azarcoya-Barrera J, van der Veen J, Leonard K, Zhao Y, Nelson R, et al.
J Nutr Biochem
. 2021 Mar;
92:108617.
PMID: 33705949
Choline is an essential nutrient required for various biological processes. Eggs, dairy, and meat are rich in phosphatidylcholine (PC), whereas cereal and legumes are rich in free choline. Excess dietary...
5.
Kennelly J, Carlin S, Ju T, van der Veen J, Nelson R, Buteau J, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Nov;
11(4):999-1021.
PMID: 33238221
Background & Aims: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved...
6.
Presa N, Dominguez-Herrera A, van der Veen J, Vance D, Gomez-Munoz A
Biochim Biophys Acta Mol Basis Dis
. 2020 Jun;
1866(10):165853.
PMID: 32502648
Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). It has been previously reported that, unexpectedly, PEMT deficiency protected from high-fat diet (HFD)-induced...
7.
Wan S, van der Veen J, Bakala NGoma J, Nelson R, Vance D, Jacobs R
FASEB J
. 2019 Jul;
33(10):10986-10995.
PMID: 31284753
Phosphatidylethanolamine (PE) -methyltransferase (PEMT) accounts for ∼30% of hepatic phosphatidylcholine (PC) biosynthesis. mice fed a high-fat diet are protected against diet-induced obesity (DIO) and insulin resistance (IR) but develop nonalcoholic...
8.
Wan S, Kuipers F, Havinga R, Ando H, Vance D, Jacobs R, et al.
Hepatol Commun
. 2019 Feb;
3(2):262-276.
PMID: 30766963
Phosphatidylethanolamine -methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. mice fed a high-fat diet (HFD)...
9.
van der Veen J, Lingrell S, McCloskey N, LeBlond N, Galleguillos D, Zhao Y, et al.
FASEB J
. 2019 Jan;
33(4):5045-5057.
PMID: 30615497
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt mice fed a high-fat diet are protected from obesity and whole-body insulin resistance. However, Pemt mice develop...
10.
Presa N, Clugston R, Lingrell S, Kelly S, Merrill Jr A, Jana S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Oct;
1865(1):14-25.
PMID: 30300671
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Pemt mice are protected from high-fat diet (HFD)-induced obesity and insulin resistance, but develop severe non-alcoholic fatty...