Susanne Lingrell
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Explore the profile of Susanne Lingrell including associated specialties, affiliations and a list of published articles.
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20
Citations
775
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Recent Articles
1.
Senger J, Rabey K, Acton L, Lin Y, Lingrell S, Chan K, et al.
J Neurosurg
. 2021 Oct;
136(5):1442-1454.
PMID: 34653977
Objective: Chronically injured nerves pose a significant clinical challenge despite surgical management. There is no clinically feasible perioperative technique to upregulate a proregenerative environment in a chronic nerve injury. Conditioning...
2.
Di Pardo A, Monyror J, Morales L, Kadam V, Lingrell S, Maglione V, et al.
Hum Mol Genet
. 2019 Dec;
29(3):418-431.
PMID: 31875875
Brain cholesterol homeostasis is altered in Huntington's disease (HD), a neurodegenerative disorder caused by the expansion of a CAG nucleotide repeat in the HTT gene. Genes involved in the synthesis...
3.
Zhao T, Goedhart C, Sam P, Sabouny R, Lingrell S, Cornish A, et al.
Life Sci Alliance
. 2019 Mar;
2(2).
PMID: 30858161
Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to...
4.
van der Veen J, Lingrell S, McCloskey N, LeBlond N, Galleguillos D, Zhao Y, et al.
FASEB J
. 2019 Jan;
33(4):5045-5057.
PMID: 30615497
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt mice fed a high-fat diet are protected from obesity and whole-body insulin resistance. However, Pemt mice develop...
5.
Presa N, Clugston R, Lingrell S, Kelly S, Merrill Jr A, Jana S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Oct;
1865(1):14-25.
PMID: 30300671
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Pemt mice are protected from high-fat diet (HFD)-induced obesity and insulin resistance, but develop severe non-alcoholic fatty...
6.
Keckesova Z, Liu Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al.
Nature
. 2017 Mar;
543(7647):681-686.
PMID: 28329758
Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that...
7.
van der Veen J, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance D, et al.
J Lipid Res
. 2017 Feb;
58(4):656-667.
PMID: 28159867
Mice lacking phosphatidylethanolamine -methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which...
8.
van der Veen J, Lingrell S, Gao X, Quiroga A, Takawale A, Armstrong E, et al.
Am J Physiol Gastrointest Liver Physiol
. 2016 Jan;
310(7):G526-38.
PMID: 26797396
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt(-/-) mice are protected against high-fat diet (HFD)-induced obesity and insulin resistance; however, these mice develop nonalcoholic fatty...
9.
Tasseva G, van der Veen J, Lingrell S, Jacobs R, Vance D, Vance J
Biochim Biophys Acta
. 2015 Nov;
1861(2):119-129.
PMID: 26603903
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. Mice lacking PEMT are protected from high-fat diet-induced obesity and insulin resistance, and exhibit increased whole-body energy expenditure...
10.
Gao X, van der Veen J, Zhu L, Chaba T, Ordonez M, Lingrell S, et al.
J Hepatol
. 2014 Nov;
62(4):913-20.
PMID: 25433161
Background & Aims: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine biosynthesis. When fed a high-fat diet (HFD), Pemt(-/-) mice are protected...