Rayman T N Tjokrodirijo
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Explore the profile of Rayman T N Tjokrodirijo including associated specialties, affiliations and a list of published articles.
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13
Citations
36
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Recent Articles
1.
Kloet M, Mukhopadhyay R, Mukherjee R, Misra M, Talavera Ormeno C, Tjokrodirijo R, et al.
Bioconjug Chem
. 2025 Feb;
PMID: 39961749
In order to effectively replicate within a host cell, the bacterium secretes effector enzymes into the cytoplasm in order to manipulate cellular host pathways including host ubiquitination. Some of these...
2.
Kloet M, Mukhopadhyay R, Mukherjee R, Misra M, Jeong M, Talavera Ormeno C, et al.
J Am Chem Soc
. 2024 Sep;
146(39):26957-26964.
PMID: 39288007
Upon infection of host cells, releases a multitude of effector enzymes into the cell's cytoplasm that hijack a plethora of cellular activities, including the host ubiquitination pathways. Effectors belonging to...
3.
Landman S, Ressing M, Gram A, Tjokrodirijo R, Van Veelen P, Neefjes J, et al.
J Biol Chem
. 2024 Aug;
300(9):107645.
PMID: 39127175
Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, persistently infects over 90% of the human adult population and is associated with several human cancers. To establish life-long infection, EBV...
4.
Brombacher E, Patente T, van der Ham A, Moll T, Otto F, Verheijen F, et al.
J Cell Biol
. 2024 Aug;
223(10).
PMID: 39115541
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism....
5.
Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status
Gelmi M, de Ru A, Van Veelen P, Tjokrodirijo R, Stern M, Houy A, et al.
Invest Ophthalmol Vis Sci
. 2024 Jul;
65(8):37.
PMID: 39042403
Purpose: Cell lines are being used in preclinical uveal melanoma (UM) research. Because not all cell lines harbor typical GNAQ or GNA11 hotspot mutations, we aimed at better classifying them...
6.
Jia Y, Oyken M, Kim R, Tjokrodirijo R, de Ru A, Janssen A, et al.
J Med Chem
. 2024 May;
67(10):7935-7953.
PMID: 38713163
The integration of diverse chemical tools like small-molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) advances clinical drug discovery and facilitates the exploration of various biological facets of...
7.
Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, et al.
ACS Chem Biol
. 2023 Aug;
18(9):2003-2013.
PMID: 37642399
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be...
8.
van den Bulk J, Verdegaal E, van der Ploeg M, Visser M, Nunes J, de Ru A, et al.
Clin Cancer Res
. 2023 Aug;
29(20):4278-4288.
PMID: 37540567
Purpose: The availability of (neo)antigens and the infiltration of tumors by (neo)antigen-specific T cells are crucial factors in cancer immunotherapy. In this study, we aimed to investigate the targetability of...
9.
Holborough-Kerkvliet M, Mucignato G, Moons S, Psomiadou V, Konada R, Pedowitz N, et al.
Glycobiology
. 2023 Jul;
33(9):732-744.
PMID: 37498177
Glycans play a pivotal role in biology. However, because of the low-affinity of glycan-protein interactions, many interaction pairs remain unknown. Two important glycoproteins involved in B-cell biology are the B-cell...
10.
Abendstein L, Dijkstra D, Tjokrodirijo R, Van Veelen P, Trouw L, Hensbergen P, et al.
Nat Commun
. 2023 Jul;
14(1):4027.
PMID: 37419978
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented...