Jacques Neefjes
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Explore the profile of Jacques Neefjes including associated specialties, affiliations and a list of published articles.
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197
Citations
8776
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Recent Articles
1.
Kosho M, Ciurli A, Giera M, Neefjes J, Loos B
J Periodontal Res
. 2025 Mar;
PMID: 40083241
Aims: To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non-periodontitis controls. This is coupled to an analysis...
2.
Boncimino F, DAuria L, Todorova K, van der Zanden S, Neefjes J, Mandinova A, et al.
Cell Death Discov
. 2025 Jan;
11(1):24.
PMID: 39863572
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature...
3.
Kastelein A, Mols F, Kervezee L, Chavannes N, Gelderblom H, Neefjes J, et al.
Cancer Med
. 2025 Jan;
14(1):e70536.
PMID: 39757797
Background: Inflammation has been reported to drive cancer-related fatigue (CRF). As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially...
4.
Stevenin V, Coipan C, Duijster J, van Elsland D, Voogd L, Bigey L, et al.
Cell Rep
. 2024 Nov;
43(11):114931.
PMID: 39488829
Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonella induces cell transformation, we performed multi-omics and phenotypic analyses of Salmonella clinical strains isolated from patients later...
5.
Jongsma M, Bakker N, Voortman L, Koning R, Bos E, Akkermans J, et al.
Curr Biol
. 2024 Sep;
34(19):4476-4494.e11.
PMID: 39276769
Kinesin and dynein-dynactin motors move endosomes and other vesicles bidirectionally along microtubules, a process mainly studied under in vitro conditions. Here, we provide a physiological bidirectional transport model following color-coded,...
6.
Landman S, Ressing M, Gram A, Tjokrodirijo R, Van Veelen P, Neefjes J, et al.
J Biol Chem
. 2024 Aug;
300(9):107645.
PMID: 39127175
Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, persistently infects over 90% of the human adult population and is associated with several human cancers. To establish life-long infection, EBV...
7.
Cabukusta B, Borst Pauwels S, Akkermans J, Blomberg N, Mulder A, Koning R, et al.
Elife
. 2024 Aug;
12.
PMID: 39106189
Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The...
8.
CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
Schoufour T, van der Plas-van Duijn A, Derksen I, Melgers M, van Veenendaal J, Lensen C, et al.
iScience
. 2024 Jun;
27(6):110120.
PMID: 38939106
Human leukocyte antigen (HLA) class-I molecules present fragments of the cellular proteome to the T cell receptor (TCR) of cytotoxic T cells to control infectious diseases and cancer. The large...
9.
Ter Linden E, Abels E, van Solinge T, Neefjes J, Broekman M
Cells
. 2024 Jun;
13(12.
PMID: 38920629
The world of cancer treatment is evolving rapidly and has improved the prospects of many cancer patients. Yet, there are still many cancers where treatment prospects have not (or hardly)...
10.
Qiao X, van der Zanden S, Li X, Tan M, Zhang Y, Song J, et al.
Mol Cancer
. 2024 Jun;
23(1):120.
PMID: 38831402
The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin and idarubicin, remains almost unmatched in oncology, despite a side effect profile including cumulative dose-dependent cardiotoxicity, therapy-related...