Robbert Q Kim
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Explore the profile of Robbert Q Kim including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
286
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Recent Articles
1.
Kloet M, Mukhopadhyay R, Mukherjee R, Misra M, Jeong M, Talavera Ormeno C, et al.
J Am Chem Soc
. 2024 Sep;
146(39):26957-26964.
PMID: 39288007
Upon infection of host cells, releases a multitude of effector enzymes into the cell's cytoplasm that hijack a plethora of cellular activities, including the host ubiquitination pathways. Effectors belonging to...
2.
Jia Y, Oyken M, Kim R, Tjokrodirijo R, de Ru A, Janssen A, et al.
J Med Chem
. 2024 May;
67(10):7935-7953.
PMID: 38713163
The integration of diverse chemical tools like small-molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) advances clinical drug discovery and facilitates the exploration of various biological facets of...
3.
Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, et al.
ACS Chem Biol
. 2023 Aug;
18(9):2003-2013.
PMID: 37642399
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be...
4.
Cremer T, Voortman L, Bos E, Jongsma M, Ter Haar L, Akkermans J, et al.
EMBO J
. 2023 Jul;
42(18):e111252.
PMID: 37519262
Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into a perinuclear quality control compartment (ERQC) for the degradation of misfolded proteins. Subsequent return to homeostasis involves clearance of the...
5.
van der Wulp W, Gram A, Bleijlevens B, Hagedoorn R, Araman C, Kim R, et al.
Front Immunol
. 2023 Jun;
14:1183914.
PMID: 37261346
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to...
6.
Mons E, Kim R, Mulder M
Pharmaceuticals (Basel)
. 2023 Apr;
16(4).
PMID: 37111304
In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. As...
7.
van Tol B, van Doodewaerd B, Lageveen-Kammeijer G, Jansen B, Talavera Ormeno C, Hekking P, et al.
Nat Commun
. 2023 Mar;
14(1):1661.
PMID: 36966155
Deubiquitinating enzymes are key regulators in the ubiquitin system and an emerging class of drug targets. These proteases disassemble polyubiquitin chains and many deubiquitinases show selectivity for specific polyubiquitin linkages....
8.
Voorneveld J, Kloet M, Wijngaarden S, Kim R, Moutsiopoulou A, Verdegaal M, et al.
J Am Chem Soc
. 2022 Nov;
144(45):20582-20589.
PMID: 36318515
We describe the development and optimization of a methodology to prepare peptides and proteins modified on the arginine residue with an adenosine-di-phosphate-ribosyl (ADPr) group. Our method comprises reacting an ornithine...
9.
Jia Y, Kim R, Kooij R, Ovaa H, Sapmaz A, Geurink P
J Med Chem
. 2022 Sep;
65(19):13288-13304.
PMID: 36149939
The multifunctional human Parkinson's disease protein 7 (PARK7/DJ1) is an attractive therapeutic target due to its link with early-onset Parkinson's disease, upregulation in various cancers, and contribution to chemoresistance. However,...
10.
Kolli S, Molina-Cruz A, Araki T, Geurten F, Ramesar J, Chevalley-Maurel S, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(35):e2209729119.
PMID: 35994647
Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of QC. We show...