Raphael Pelossof
Overview
Explore the profile of Raphael Pelossof including associated specialties, affiliations and a list of published articles.
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16
Citations
665
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0
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Recent Articles
1.
Chatila W, Kim J, Walch H, Marco M, Chen C, Wu F, et al.
Nat Med
. 2022 Aug;
28(8):1646-1655.
PMID: 35970919
The incidence of rectal cancer is increasing in patients younger than 50 years. Locally advanced rectal cancer is still treated with neoadjuvant radiation, chemotherapy and surgery, but recent evidence suggests...
2.
Choi S, Kim J, Chen C, Wu C, Marco M, Barriga F, et al.
Mol Cancer Res
. 2022 Apr;
20(8):1305-1319.
PMID: 35394541
Implications: Knocking-out ITGB4, which is overexpressed in KRAS-mutant colorectal cancer and promotes tumor aggressiveness, diminishes local invasiveness and rates of pulmonary metastasis.
3.
Ahmed T, Carty M, Wenric S, Dry J, Salahudeen A, Khan A, et al.
Brief Bioinform
. 2022 Apr;
23(3).
PMID: 35388408
Reproducibility of results obtained using ribonucleic acid (RNA) data across labs remains a major hurdle in cancer research. Often, molecular predictors trained on one dataset cannot be applied to another...
4.
Kim J, Marco M, Choi S, Qu X, Chen C, Elkabets M, et al.
Mol Oncol
. 2021 Apr;
15(10):2766-2781.
PMID: 33817986
Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully understood. We profiled mRNA in 76...
5.
Ganesh K, Wu C, ORourke K, Szeglin B, Zheng Y, Gabriel Sauve C, et al.
Nat Med
. 2019 Oct;
25(10):1607-1614.
PMID: 31591597
Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental...
6.
Novoplansky O, Fury M, Prasad M, Yegodayev K, Zorea J, Cohen L, et al.
Int J Cancer
. 2019 Jan;
145(3):748-762.
PMID: 30694565
An understanding of the mechanisms underlying acquired resistance to cetuximab is urgently needed to improve cetuximab efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Here, we present...
7.
Ben-Aharon I, Elkabets M, Pelossof R, Yu K, Iacubuzio-Donahue C, Leach S, et al.
Clin Cancer Res
. 2019 Jan;
25(7):2185-2193.
PMID: 30617137
Purpose: State-of-the-art genomic analyses of pancreatic adenocarcinoma (PDAC) have yielded insight into signaling pathways underlying carcinogenesis. PDAC is characterized by substantial genomic heterogeneity. We aimed to determine whether early-onset PDAC...
8.
Marco M, Zhou L, Patil S, Marcet J, Varma M, Oommen S, et al.
Dis Colon Rectum
. 2018 Sep;
61(10):1146-1155.
PMID: 30192323
Background: Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in the proportion of rectal cancer patients with a...
9.
Carty M, Zamparo L, Sahin M, Gonzalez A, Pelossof R, Elemento O, et al.
Nat Commun
. 2017 May;
8:15454.
PMID: 28513628
Here we present HiC-DC, a principled method to estimate the statistical significance (P values) of chromatin interactions from Hi-C experiments. HiC-DC uses hurdle negative binomial regression account for systematic sources...
10.
Pelossof R, Fairchild L, Huang C, Widmer C, Sreedharan V, Sinha N, et al.
Nat Biotechnol
. 2017 Mar;
35(4):350-353.
PMID: 28263295
We present SplashRNA, a sequential classifier to predict potent microRNA-based short hairpin RNAs (shRNAs). Trained on published and novel data sets, SplashRNA outperforms previous algorithms and reliably predicts the most...