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Genes, Chromosomes & Cancer

'Genes, Chromosomes & Cancer' is a renowned scientific journal that focuses on the study of genetic and chromosomal abnormalities in relation to cancer development and progression. It publishes cutting-edge research articles, reviews, and commentaries, providing valuable insights into the molecular mechanisms underlying cancer and potential therapeutic targets. The journal serves as a vital resource for researchers, clinicians, and students interested in understanding the complex interplay between genes, chromosomes, and cancer.
Details
Abbr. Genes Chromosomes Cancer
Start 1989
End Continuing
Frequency 12 no. a year
p-ISSN 1045-2257
e-ISSN 1098-2264
Country United States
Language English
Specialties Oncology
Molecular Biology
Metrics
h-index / Ranks: 1919 130
SJR / Ranks: 3180 1110
CiteScore / Ranks: 1970 8.60
JIF / Ranks: 2561 3.7
Recent Articles
1.
EWSR1::CREM Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor
Lilley M, Blackburn P, Furtado L, Pappo A, Koo S
Genes Chromosomes Cancer . 2025 Mar; 64(3):e70038. PMID: 40072299
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of...
2.
Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment
Rambo M, Agarwala I, Vanek C, Xiao Y, Brown E, Mills K
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70036. PMID: 39996425
Background And Aims: Plexiform neurofibromas (PNFs) are benign tumors of the peripheral nervous system that affect approximately 30% of people with neurofibromatosis type 1 (NF1). Schwann cells (SCs), the tumor...
3.
FIP1L1::PDGFRA Fusion in a Pediatric Patient Presenting With B-Cell Lymphoblastic Leukemia
Nunn J, Williams B, Deambrosis D
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70037. PMID: 39996417
Approximately 10% of Ph-Like patients have ABL class gene fusions, which include the FIP1L1::PDGFRA rearrangement. We report a case of a pediatric patient with Ph-like B-lymphoblastic leukemia (B-LL) with a...
4.
A MAZ::NCOA2 Subcutaneous Small Round Cell Sarcoma of Infancy With Diffuse S100/SOX10 Positivity: A Novel Entity
Chen H, Zhang P, Zhou L
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70034. PMID: 39985329
Small round cell sarcomas (SRCSs) constitute a heterogeneous group of high-grade tumors with a poor prognosis, predominantly affecting children and young adults. According to the 2020 WHO Soft Tissue Tumor...
5.
Pregnancy and the Risk for Cancer in Neurofibromatosis 1
Kallionpaa R, Maattanen J, Leppavirta J, Peltonen S, Peltonen J
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70017. PMID: 39985314
Background: Neurofibromatosis type 1 (NF1) is associated with a high risk for cancer. Benign cutaneous neurofibromas of women with NF1 may increase in size and number during pregnancy. However, it...
6.
A Novel ACVR2A::RAF1 Fusion in Spindle Cell Sarcoma
Jiang A, Li H, Li D, Chen H, Zhao L, Zhang Y, et al.
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70033. PMID: 39950347
Background: Kinase-rearranged spindle cell sarcomas are characterized by unique molecular features. The advent of next-generation sequencing (NGS) has enabled the detection of a multitude of kinase fusions, thereby contributing to...
7.
PDGFRA::USP8 Fusion in a Cutaneous Inflammatory Myofibroblastic Tumor, Highlighting Genetic Pleiotropy of Kinase Gene Fusions in Soft Tissue Neoplasms
Vernemmen A, van Kempen L, Aarts F, Zur Hausen A, Sciot R, Hornick J, et al.
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70035. PMID: 39950323
USP8 fusions have recently been described in neoplasms in the provisional category of calcified chondroid mesenchymal neoplasm (CCMN). Here, we describe a cutaneous inflammatory myofibroblastic tumor (IMT) on the upper...
8.
Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer
Zou M, Qiu L, Wu W, Liu H, Xiao H, Liu J
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70030. PMID: 39936880
Identifying genes involved in cancer is crucial for understanding the underlying molecular mechanisms of the disease and developing effective treatment strategies. Differential expression analysis (DEA) is the predominant method used...
9.
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values
Wu S, Pan J, Citartan M, Tang T, Teo S, Chng E
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70027. PMID: 39936877
Breast cancer, a molecularly heterogeneous disease, is classified into hormone receptor-positive luminal breast cancer (LBC), human epidermal growth factor receptor 2-positive breast cancer, and triple-negative breast cancer (TNBC). Precursor microRNAs...
10.
Influence of Cytogenetics on the Outcome of Patients With High-Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide
Rasmussen B, Nilsson L, Tobiasson M, Jadersten M, Garelius H, Dybedal I, et al.
Genes Chromosomes Cancer . 2025 Feb; 64(2):e70029. PMID: 39921387
In myelodysplastic syndromes (MDS), cytogenetic characteristics of the malignant bone marrow cells influence the clinical course. The aim of this study was to evaluate whether cytogenetics is useful to predict...