KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2022 Apr 8

PMID 35394541

Authors

Seo-Hyun Choi

Jin K Kim

Chin-Tung Chen

Chao Wu

Michael R Marco

Francisco M Barriga

Kevin ORourke

Raphael Pelossof

Xuan Qu

Qing Chang

Elisa de Stanchina

Jinru Shia

J Joshua Smith

Francisco Sanchez-Vega

Julio Garcia-Aguilar

Affiliations

Soon will be listed here.

Abstract

Implications: Knocking-out ITGB4, which is overexpressed in KRAS-mutant colorectal cancer and promotes tumor aggressiveness, diminishes local invasiveness and rates of pulmonary metastasis.

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