Ralph Scully
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Explore the profile of Ralph Scully including associated specialties, affiliations and a list of published articles.
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69
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4099
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Recent Articles
11.
Scully R, Elango R, Panday A, Willis N
Curr Opin Genet Dev
. 2021 Aug;
71:154-162.
PMID: 34464818
Replication fork stalling occurs when the replisome encounters a barrier to normal fork progression. Replisome stalling events are common during scheduled DNA synthesis, but vary in their severity. At one...
12.
Etourneaud L, Moussa A, Rass E, Genet D, Willaume S, Chabance-Okumura C, et al.
Sci Adv
. 2021 Aug;
7(35).
PMID: 34452908
Double-strand breaks (DSBs) are harmful lesions and a major cause of genome instability. Studies have suggested a link between the nuclear envelope and the DNA damage response. Here, we show...
13.
Panday A, Willis N, Elango R, Menghi F, Duffey E, Liu E, et al.
Mol Cell
. 2021 Apr;
81(11):2428-2444.e6.
PMID: 33882298
Repair pathway "choice" at stalled mammalian replication forks is an important determinant of genome stability; however, the underlying mechanisms are poorly understood. FANCM encodes a multi-domain scaffolding and motor protein...
14.
Willis N, Scully R
Methods Mol Biol
. 2020 Aug;
2153:329-353.
PMID: 32840790
Site-specific replication fork barriers (RFBs) have proven valuable tools for studying mechanisms of repair at sites of replication fork stalling in prokaryotes and yeasts. We adapted the Escherichia coli Tus-Ter...
15.
Luo M, Zheng F, Chen W, Liang Z, Chandramouly G, Tan J, et al.
Cancer Res
. 2020 Mar;
80(14):3033-3045.
PMID: 32193285
PARP inhibitor monotherapies are effective to treat patients with breast, ovary, prostate, and pancreatic cancer with BRCA1 mutations, but not to the much more frequent BRCA wild-type cancers. Searching for...
16.
Monteiro A, Bouwman P, Kousholt A, Eccles D, Millot G, Masson J, et al.
J Med Genet
. 2020 Mar;
57(8):509-518.
PMID: 32152249
No abstract available.
17.
Scully R, Panday A, Elango R, Willis N
Nat Rev Mol Cell Biol
. 2019 Jul;
20(11):698-714.
PMID: 31263220
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining genomic stability. However, if deployed in an inappropriate cellular context, these same repair functions can mediate chromosome...
18.
Willis N, Panday A, Duffey E, Scully R
PLoS Genet
. 2018 Jul;
14(7):e1007486.
PMID: 30024881
Classical non-homologous end joining (C-NHEJ) and homologous recombination (HR) compete to repair mammalian chromosomal double strand breaks (DSBs). However, C-NHEJ has no impact on HR induced by DNA nicking enzymes....
19.
Menghi F, Barthel F, Yadav V, Tang M, Ji B, Tang Z, et al.
Cancer Cell
. 2018 Jul;
34(2):197-210.e5.
PMID: 30017478
The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into...
20.
Willis N, Frock R, Menghi F, Duffey E, Panday A, Camacho V, et al.
Nature
. 2017 Nov;
551(7682):590-595.
PMID: 29168504
Small, approximately 10-kilobase microhomology-mediated tandem duplications are abundant in the genomes of BRCA1-linked but not BRCA2-linked breast cancer. Here we define the mechanism underlying this rearrangement signature. We show that,...