Ralph Scully
Overview
Explore the profile of Ralph Scully including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
4099
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Recent Articles
21.
Nath S, Somyajit K, Mishra A, Scully R, Nagaraju G
Nucleic Acids Res
. 2017 Sep;
45(15):8886-8900.
PMID: 28911102
The FANCJ DNA helicase is linked to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been implicated in the repair...
22.
Hwang Y, Futran M, Hidalgo D, Pop R, Iyer D, Scully R, et al.
Sci Adv
. 2017 Jun;
3(5):e1700298.
PMID: 28560351
Cell cycle regulators are increasingly implicated in cell fate decisions, such as the acquisition or loss of pluripotency and self-renewal potential. The cell cycle mechanisms that regulate these cell fate...
23.
Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al.
Sci Rep
. 2017 Mar;
7:44662.
PMID: 28317934
DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes cells to DNA double strand...
24.
Hartlerode A, Willis N, Rajendran A, Manis J, Scully R
PLoS Genet
. 2016 Dec;
12(12):e1006509.
PMID: 27959912
[This corrects the article DOI: 10.1371/journal.pgen.1006410.].
25.
Hartlerode A, Willis N, Rajendran A, Manis J, Scully R
PLoS Genet
. 2016 Nov;
12(11):e1006410.
PMID: 27832076
A proportion of homologous recombination (HR) events in mammalian cells resolve by "long tract" gene conversion, reflecting copying of several kilobases from the donor sister chromatid prior to termination. Cells...
26.
Guirouilh-Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez B
PLoS Genet
. 2016 Nov;
12(10):e1006230.
PMID: 27798638
DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring...
27.
Willis N, Scully R
Mol Cell
. 2016 Aug;
63(4):542-544.
PMID: 27540853
Using a combination of genetics and cellular DNA rejoining assays, in this issue of Molecular Cell, Wyatt et al. (2016) demonstrate a critical role for mammalian DNA polymerase θ in...
28.
Juvekar A, Hu H, Yadegarynia S, Lyssiotis C, Ullas S, Lien E, et al.
Proc Natl Acad Sci U S A
. 2016 Jul;
113(30):E4338-47.
PMID: 27402769
We previously reported that combining a phosphoinositide 3-kinase (PI3K) inhibitor with a poly-ADP Rib polymerase (PARP)-inhibitor enhanced DNA damage and cell death in breast cancers that have genetic aberrations in...
29.
Willis N, Scully R
Cell Cycle
. 2016 May;
15(14):1812-20.
PMID: 27136113
The Escherichia coli replication fork arrest complex Tus/Ter mediates site-specific replication fork arrest and homologous recombination (HR) on a mammalian chromosome, inducing both conservative "short tract" gene conversion (STGC) and...
30.
Menghi F, Inaki K, Woo X, Kumar P, Grzeda K, Malhotra A, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(17):E2373-82.
PMID: 27071093
Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is...